Lidocaine Decreases Postoperative Lung Cancer Reoccurance and Metatasis Risk

Korábbi kezelés

• Palliative surgery without intention of cure.
• Concurrent use with continuous infusion of other local anesthetic drugs (such as epidural).
• Patients who use drugs that may cause reasons for exclusion, including Class I and Class III antiarrhythmic drugs (such as mexiletine and amiodarone), cimetidine, and antiviral drugs. Eligibility will be determined by local clinicians and verified by clinical trial doctors.

Más betegség

• Patients with known or suspected allergy to lidocaine.
• Epilepsy.

Laborértékek

• Currently, there is abnormal liver function, with ALT or AST levels exceeding the laboratory reference range by a factor of 2.
• Currently, there is severe renal insufficiency (serum creatinine ≥451umol/L or glomerular filtration rate (calculated using the MDRD formula) <30ml/min).
• Patients with cardiac conduction abnormalities, including second-degree or third-degree heart block without a pacemaker, left bundle branch block, sick sinus syndrome, and pre-excitation syndrome (confirmed by medical history and electrocardiogram), as well as those with low cardiac output due to reduced left ventricular ejection fraction.

Egyéb

• Extensive comorbidities (ASA IV).
• Patients who are currently pregnant or breastfeeding.
• Patients who may experience adverse reactions due to accumulation of lidocaine during intravenous infusion, as stated in the Summary of Product Characteristics (SmPC) for lidocaine.
• Patients with body weight <40kg

• Age range: 18-80 years old.
• Electively undergo minimally invasive (thoracoscopic or robotic) surgery for the treatment of lung cancer
• Is willing and capable of providing consent.