CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC

Korábbi kezelés

• History of prior treatment for medullary thyroid carcinoma (e.g., surgery, radiotherapy, targeted therapy, radionuclide therapy, or interventional therapy).
• Assessed as not being a surgical candidate or refusal to undergo surgery;

Más betegség

• History of other malignant tumors;
• Known allergy to contrast agents;
• Claustrophobia or other psychiatric disorders that may preclude compliance with study procedures;
• Any other condition deemed by the investigator to make the participant unsuitable for the study.

Laborértékek

• Major organ dysfunction, defined as:
  • Bone marrow impairment: WBC ≤ 4.0×10⁹/L or neutrophils ≤ 1.5×10⁹/L; platelets ≤ 100×10⁹/L; hemoglobin ≤ 90 g/L
  • Hepatic impairment: PT or APTT ≥ 1.5 × ULN; total bilirubin ≥ 1.5 × ULN; ALT/AST ≥ 2.5 × ULN (or ≥ 5 × ULN in participants with liver metastases); ALP ≥ 2.5 × ULN (or ≥ 4.5 × ULN in cases with bone or liver metastases)
  • Renal impairment: BUN ≥ 1.5 × ULN; serum creatinine ≥ 1.5 × ULN

Egyéb

• Women who are planning pregnancy, currently pregnant, or breastfeeding.
• Inability to lie flat for at least 30 minutes;
• Unwillingness to participate in the clinical trial;

• Newly-diagnosed medullary thyroid carcinoma meeting either criterion a or criteria b + c:
  • Pathologically or cytologically confirmed diagnosis;
  • Elevated serum calcitonin level (>10 pg/mL);
  • Other infectious or neoplastic diseases excluded.
• Life expectancy ≥ 12 weeks;
• ECOG performance status of 0 or 1;
• Absence of distant metastasis confirmed by conventional imaging, with resectable locoregional disease;
• Scheduled to undergo surgery within 30 days;
• Females of childbearing potential must use effective contraception (e.g., sterilization, intrauterine device, condoms, oral/injectable contraceptives, abstinence, or partner vasectomy) during the study and for 6 months after study completion. Male participants must agree to use effective contraception during the same period;
• Capable of understanding and voluntarily signing the informed consent form with good compliance.