Effectiveness of Genistein in Mild Cognitive Impairment

Más betegség

• Diagnosis of a significant neurological disease other than Alzheimer's disease.
• Moderate depression as assessed by a Geriatric Depression Scale (GDS-D) score >8, or any other serious psychiatric disorder.
• Having a hormone-dependent neoplastic disease.
• Diagnosis of significant cerebrovascular disease.
• Having a serious systemic illness that would prevent completion of the study.

Egyéb

• Taking supplements containing isoflavones.

• Patient over 50 years of age.
• Patient diagnosed with mild cognitive impairment (MCI) for Alzheimer's disease (AD) according to the National Institute on Aging and Alzheimer's Association (NIA-AA, 2024) criteria:
  • MMSE scores between 22 and 30 (inclusive; exceptions may be made for subjects with less than 5 years of education).
  • Evidence of concern about change in cognition, compared to the person's previous level (subjective memory complaint/impairment for more than 6 months in the past year and/or confirmed by the informant and/or physician).
  • A Clinical Dementia Rating (CDR) score of 0.5 with a memory domain score of 0.5.
  • Essentially preserved activities of daily living.
• Evidence of elevated cortical amyloid by positron emission tomography (PET) with F18-flutemetamol. • Patients will be treated pharmaceutically according to the guidelines.