Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer

Korábbi kezelés

• Prior exposure to chemotherapy.
• Concomitant use of any drug has anti-oxidant activity or neuroprotective agent.
• Patients take any medication that increase acetyle choline either central or peripheral.

Más betegség

• Patients with diabetes and other conditions that predispose to neuropathy.
• History of known allergy to oxaliplatin or other platinum agents.
• Patient was any cardiac disease.

Életkor

• Children < 18 years old.

Egyéb

• Pregnant and breastfeeding women.

• Males and females aged ≥ 18 years old.
• Patients with histologically confirmed diagnosis of Stage III colorectal cancer and high risk Stage II.
• Patients who will be scheduled to receive modified FOLFOX-6.
• Patients with no contraindication to chemotherapy.
• Adequate baseline hematologic values (absolute neutrophilic count ≥ 1.5
  • 109/L, platelet count ≥ 100 × 109/L and hemoglobin level ≥ 10 g/dl).
• Patients with adequate renal function (serum creatinine < 1.5 mg/dl or creatinine clearance (ClCr) ˃ 45 mL/min).
• Patients with adequate liver function (serum bilirubin < 1.5 mg/dl).
• Patients with performance status 0-1 according to Eastern Cooperative Oncology Group (ECOG) score.