Speech-based Assessment of Relapse Risk in People With Psychosis

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• Healthy participants Inclusion Criteria:
• Between 18 and 65 years old.
• Subjects must be able to provide informed consent (IC).
• Participants must have provided signed informed consent prior to enrollment.
• Participants should not take prescription drugs regularly.
• Native or equivalent fluency in speaking and understanding one of the following languages: English, German, Dutch, French, Czech or Turkish.
• Ability to have access to a smartphone and be capable of using a mobile app for speech-based data collection.
• Must be able to comply with the study schedule and procedures.
  • Healthy participants Exclusion Criteria:
• Any history of major diseases (e.g., cardiovascular, neurological, metabolic, renal, hepatic, respiratory or speech disorders).
• Recreational drug use or psychiatric disorders due to use of alcohol.
• Depression, anxiety, or other psychiatric disorders.
• Family history of depression, anxiety, or other psychiatric disorders.
• Individuals who are not able or willing to understand the purpose and details of the study.
  • Individuals with psychosis Inclusion Criteria:
• Between 18 and 65 years old.
• Diagnoses include psychotic disorders (schizophrenia, schizoaffective disorder, schizophreniform disorder, acute psychosis, bipolar disorder with psychotic symptoms, psychosis not otherwise specified).
• First visit must be during remission phase (baseline measurement).
• Current positive symptoms rated 3 (mild) or lower on all of these Brief Psychiatric Symptom Scale (BPRS) items: hallucinatory behavior, unusual thought content, conceptual disorganization.
• Must be able to comply with the study schedule and procedures.
• Subjects must be able to provide IC.
• Participants must have provided signed informed consent prior to enrollment.
• Native or equivalent fluency in speaking and understanding one of the following languages: English, German, Dutch, French, Czech or Turkish.
• Ability to have access to a smartphone and be capable of using a mobile app for speech-based data collection.
  • Individuals with psychosis Exclusion Criteria:
• Severe comorbid speech disorders (aphasia or severe stuttering) that prevent adequate speech recording.
• Individuals who are not able or willing to understand the purpose and details of the investigation.
  • Citizens with psychiatric or somatic comorbidity, drug- or alcohol abuse will be allowed to participate, so that the sample will reflect the general population of citizens with psychosis and the study's endpoints will be generalizable.