Auditory Stimulation During Sleep to Enhance Long-Term Memory in Amnestic MCI

Korábbi kezelés

• Diagnosed for depression or any severe psychiatric disorder in the 5 years prior to the evaluation
• Changes in treatment with benzodiazepines or antidepressants in the 6 months prior to the initial evaluation
• Treatment with neuroleptics

Más betegség

• Patients with severe and/or complex chronic systemic diseases: Advanced heart disease, Advanced chronic kidney disease, for example, stage 4 or 5, Severe lung disease, such as GOLD stage III-IV COPD, Metastatic or end-stage cancer, Severe hematologic disorders, Active or chronic uncontrolled infectious diseases (e.g., untreated HIV)
• Evidence of strategic infarcts or other findings on neuroimaging that could be the cause of secondary cognitive impairment
• Epilepsy with active treatment (within the last 5 years) or any comorbidity with a neurological disease that may cause cognitive impairment or brain damage

Egyéb

• Abuse of alcohol or other psychotropic substances
• Illiteracy
• Moderate or severe sleep apnea (without CPAP during the study)

• Age range > 50 years and ≤ 75 years
• Native Spanish speaker
• Normal or corrected-to-normal color vision
• Diagnosis of Alzheimer's disease with an amnestic phenotype at the mild cognitive impairment stage, confirmed according to the current clinical criteria of NIA-AA (2024) and IWG (2024), as well as the clinical protocols of the treating hospital
• Sufficient hearing without the use of a hearing aid (participant with a hearing threshold of 50 dB or higher in the calibration night hearing test will be excluded)