Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function

A regiszterben nem jelölt feltételek

• Inclusion criteria:
  • Patients eligible for inclusion in this study must meet all of the following criteria:
• Diagnosis of Parkinson's Disease by a neurologist according to the Movement Disorder Society Clinical Diagnostic Criteria for PD
• Signed informed consent form
• Aged 18-75 years old
• Able to understand the study and questionnaires, and comply with study requirements
  • Controls eligible for inclusion in this study must meet all of the following criteria:
• Aged 40-75 years old
• Signed informed consent form
• Able to understand the study and questionnaires, and comply with study requirements
  • Exclusion criteria:
  • Participants eligible for this study must not meet any of the following criteria:
  • Patients and controls:
• Gastrointestinal: diagnosis of organic gastrointestinal diseases potentially affecting the assessments during the study (e.g. inflammatory bowel disease (IBD), celiac disease, eosinophilic diseases of the gastro-intestinal tract, gastro-intestinal cancer, diverticulitis in the last 6 months, GI infection in the last 3 months, …).
• Surgery: major abdominal surgery (including, but not limited to: cholecystectomy, colectomy, hiatal hernia repair, …) except for uncomplicated appendectomy, splenectomy and inguinal hernia repair.
• Medication use:
  • Any previous exposure to medication used in the treatment of motor symptoms of Parkinson's disease (levodopa, dopamine agonists, MAO-B inhibitors, COMT-inhibitors, NMDA-receptor antagonists, anticholinergics)
  • Antibiotics use in the last 3 months.
  • Use of PPI in the last month.
  • Use of NSAID in the last month.
  • Use of anticoagulation4 (including vitamin K antagonists (VKA), direct oral anticoagulants (DOAC) or low-molecular weight heparins (LMWH)) or dual antiplatelet therapy4 (DUAPT; Acetylsalicilic acid (Asaflow®) + P2Y12-inhibitor (Clopidogrel®)).
• Pregnancy and breastfeeding.
• Other: Cancer and/or adjuvant treatment within the last 6 months
• Exposures:
  • Food intoxication in the last 3 months.
  • Consumptom of more than 2 standard units of alcohol per day.
  • Patients (additional criteria)
• Neurological: any major neurological disorder other than Parkinson's disease.
  • Controls (additional criteria)
• Neurological:
  • A diagnosis of Parkinson's disease or any other major neurological disorder other than Parkinson's disease.
  • Clinical signs of parkinsonism.
  • First degree relative(s) with Parkinson's disease.
• Gastrointestinal: subjects fulfilling a clinical diagnosis of either Functional dyspepsia, Functional constipation, or Irritable bowel syndrome based on the ROME-IV diagnostic criteria.