Hyperbaric Oxygen Therapy for Persistent Post Stroke Depression

Korábbi kezelés

• Diagnosis of a psychiatric disorder prior to the recent stroke including: major depression, schizophrenia or bipolar disease.
• HBOT for any reason prior to study enrolment

Más betegség

• History of Deep brain stimulation (DBS)
• History of traumatic brain injury, brain tumors, brain surgery, chronic subdural haemorrhages, Epilepsy
• Active malignancy
• History of other neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (LBD), Frontotemporal dementia (FTD), Multiple sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Creutzfeld Jacob disease (CJD), Multisystem atrophy (MSA), Pseudobulbar palsy (PSP), Corticobasal degeneration (CBD), Wernicke Korsakoff syndrome
• Renal or liver insufficiency, electrolyte imbalances

Laborértékek

• Chronic heart failure with ejection fraction of 30 or less

Egyéb

• Inability to attend scheduled clinic visits and/or comply with the study protocol
• Diagnosis of aphasia or major cognitive decline
• Substance use at baseline.
• Serious suicidal ideation
• Chest pathology incompatible with pressure changes (including active asthma or COPD)
• Ear or Sinus pathology incompatible with pressure changes (above 3 otolaryngologist visits a year)
• An inability to perform an awake brain MRI
• No evidence of vascular related lesions in the brain MRI
• Active smoking
• Participation in another study

• Age between 50 -85
• Suffered an ischemic stroke 6 months to 7 years prior to their inclusion
• Treated or being treated by antidepressants for at least 3 months
• Diagnosis of PSD based on HDRS-17 score of 17 and above.
• Stable psychological and pharmacological treatment for more than three months prior to inclusion.
• Subject willing and able to read, understand and sign an informed consent.