Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)

Más betegség

• Known cardiovascular disease such as hypertension or atherosclerosis, and/or use of an anti-hypertensive medication
• Known renal disease or microalbuminuria, and/or use of angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blockers (ARBs) for microalbuminuria
• Raynaud's phenomenon or other vascular disease
• Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation of the study results.

Laborértékek

• Any disease other than type 1 diabetes that affects glucose, sex steroid, or fat metabolism such as polycystic ovary syndrome or hypercortisolism
• Any medication use that may affect glucose, sex steroid, or fat metabolism such as metformin or glucocorticoids
• Known hyperlipidemia, defined as LDL ≥ 160 mg/dL, and/or use of lipid-lowering medication, such as statin therapy

Egyéb

• Half or full sibling already participating in this study
• Known diabetic retinopathy or neuropathy
• Obesity and/or body habitus that precludes completion of the flow-mediated brachial ultrasound study (generally, BMI > 40 kg/m2 in adults) - this is at study team's discretion.
• Pregnancy or lactation

• Aged 15-24 years
• Clinical diagnosis of type 1 diabetes, requiring insulin therapy, of ≥ 1 to < 10 years duration.
• Last available HbA1c ≤ 8.5% (obtained by chart review in Children's Wisconsin Diabetes Clinic patients or verbally by individuals not receiving diabetes care at Children's Wisconsin)
• Current use of an FDA approved automated insulin delivery (AID) system
• Willing to consume a 12 ounce Gatorade G Zero Glacier Cherry drink in less than 10 minutes
• Willing and able to give informed consent or have parent or legal guardian provide informed consent if the subject is < 18 years of age