Buspirone for Anxiety in Autistic Youth

Korábbi kezelés

• Any past or present conditions that would make treatment with buspirone unsafe
• Current use of any of the following psychotropic medications: SSRIs, SNRIs, mirtazapine, benzodiazepines, tricyclic antidepressants, monoamine oxidase inhibitors, mood stabilizers, or antipsychotics
• Previous adequate trial of buspirone (≥20 mg/day for at least 4 weeks) or significant adverse effects

Más betegség

• Known diagnosis of a genetic syndrome associated with ASD (e.g. Fragile X syndrome, Angelman syndrome) based on parent report
• Known cardiac arrythmia based on parent report
• Current primary diagnosis of bipolar disorder, psychosis, substance use disorder, posttraumatic stress disorder, eating disorder, or major depressive disorder in the opinion of the PI
• Acutely unstable medical/psychiatric condition (e.g. self-injury, suicidality) that would preclude study participation in the opinion of the PI
• Inability to tolerate Bittium Faros device in the opinion of the parent or a known allergy to adhesives

Életkor

• Pregnancy or sexual activity without the use of an acceptable form of birth control in females of childbearing age

Egyéb

• Aberrant Behavior Checklist Irritability subscale score (ABC-I) ≥18

• Age 7-17 years
• Diagnosis of Autism Spectrum Disorder (ASD) confirmed by the study clinician using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and Social Communication Questionnaire (SCQ)
• Diagnosis of social phobia, separation anxiety disorder, or generalized anxiety disorder of at least moderate severity based on the Anxiety and Related Disorders Interview Schedule (ADIS), 5-item Pediatric Anxiety Rating Scale (PARS) score ≥10, and Clinical Global Impression Severity subscale (CGI-S) ≥4
• IQ ≥50 based on Stanford Binet, 5th Edition Abbreviated IQ test or the Kaufman Brief Intelligence Test, 2nd Edition (KBIT-2)
• Stable medications for ≥30 days
• English speaking
• Ability to swallow buspirone capsules or liquid suspension