NCT07441928Toboroz
Effects of Smoking on Network Connectivity in Patients With Schizophrenia Symptoms in Scz Patients
Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Acceptance and Commitment Therapy for Smoking Cessation and Reduction of Psychotic Symptoms in Patients With Schizophrenia
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. márc. 2.
Rövid összefoglaló (regiszter, angolul)
The prevalence of smoking among people with schizophrenia (SCZ) is substantially higher at 54% to 90% (McClave et al., 2010). About half of all deaths amongst people with scz are attributed to smoking-related diseases and cancer involving the lung, the cardiovascular system, and the liver (Kely et al., 2011; WHO, 2019). Acceptance and commitment therapy (ACT) is effective for treating psychotic symptoms and addictive behaviours. In a local randomised controlled trial comparing individual ACT to social support for smoking cessation in adult scz smokers, the self-reported quit rates in ACT group were higher than in the social support group (6 months: 12.3% vs. 7.7%, p=0.56 ; 12 months: 10.8% vs. 7.7%, p=0.76; Mak, Loke, and Leung, 2021). In this study, functional neuroimaging (fMRI) will be combined with symptoms assessment in order to ascertain whether group-based ACT is effective in modifying the brain's responses in general and specifically to tobacco craving cues and resting-state functional connectivity in three time points (pre-, post-intervention, and 6-month follow-up) among people with schizophrenia.
- Állapot (regiszter)
- Toboroz
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 90 (tervezett)
- Első benyújtás
- 2026. febr. 23.
- Kezdés
- 2023. márc. 1.
- Elsődleges befejezés
- 2026. ápr. 30.
- Fő szponzor
- The Hong Kong Polytechnic University
- Betegségek
- Skizofrénia
- NCT-szám
- NCT07441928
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Tervezett résztvevők: 90
- 2023. márc. 1. és az elsődleges befejezés (2026. ápr. 30.) között
- 5 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Korábbi kezelés
- Have a lifetime history of substance abuse and/or are currently receiving treatment for substance abuse (e.g., opioids, cocaine, marijuana, or stimulants);
- Have received a diagnosis of alcohol or drug dependence in the year preceding recruitment;
Más betegség
- Have any other current or past psychotic disorders;
- with a known history of violence/aggression and a forensic history
- Have a history or current diagnosis of attention-deficit hyperactivity disorder (ADHD);
- Have a history of epilepsy or a seizure disorder;
- Experience disorientation, have developmental disabilities, and/or an organic mental disorder;
Egyéb
- with fleeting or actual suicidal/self-harm ideations, or acting-out behavior in the past;
- Categorized with special care or intensive care (e.g., arson, battery, physical assault, rape, murder, etc.)
- With alcohol consumption exceeding 25 standard drinks/week for men and 20 standard drinks/week for women over the last 6 months;
- Are pregnant, breast-feeding, or planning a pregnancy for the duration of the study;
- fMRI-related exclusion criteria promulgated by University Research Facility in Behavioural and Systems Neuroscience (UBSN), PolyU
Kiket keres a vizsgálat
- Individuals who have been diagnosed with schizophrenia or schizoaffective disorder and after at least one-year followup;
- currently taking anti-psychotic medications for ≥ 3 months with good compliance;
- aged 18 years or above;
- able to communicate in Cantonese
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (5)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Out-patient Clinic (Psy), Pamela Youde Nethersole Eastern Hospital | Hong Kong | Hongkong | Toboroz |
| The Society of Rehabilitation and Crime Prevention | Hong Kong | Hongkong | Toboroz |
| Lok Hong Integrated Community Centre for Mental Wellness, Tung Wah Group of Hospitals | Hong Kong | Hongkong | Toboroz |
| The Mental Health Association of Hong Kong | Hong Kong | Hongkong | Toboroz |
| Mental Health and Development, Christian Family Service Centre | Hong Kong | Hongkong | Toboroz |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.