FAST-M: Prolonged Overnight Fasting and Mediterranean Dietary Intervention for Patients With Multiple Myeloma or Its Precursor Disease

Más betegség

• History of a clinical eating disorder.
• History of dementia or major psychiatric disease.
• History of recent (≤1 yr) stroke, myocardial infarction or congestive heart failure.
• History of autoimmune disease and on treatment at time of screening.

Életkor

• Individuals younger than 18 years of age.

Egyéb

• Unable to provide consent.
• Unable to read or understand English or Spanish.
• Any contraindication for diet changes as determined by physician.

• 18 years of age or older.
• Any sex/gender.
• Able to provide consent.
• Able to speak, read, and understand English or Spanish.
• Diagnosis of Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM), or Multiple Myeloma (MM) per standard criteria:
  • Cohort 1 - Participants must have a confirmed diagnosis of MGUS and SMM.
  • Cohort 2 - Participants must have a confirmed new diagnosis of MM and be initiating anti-myeloma therapy.
• Delivery of anti-myeloma therapies at one of the following institutions:
  • Sylvester Comprehensive Cancer Center (SCCC) (including satellite/network sites).
  • University of Miami Health System.
• Approval from treating oncologist, confirmed via email or in writing.
• Eastern Cooperative Oncology Group (ECOG) Performance Status grade of <2
  • PI approval needed if ECOG ≥ 2.
• Having not consistently (not equal to or more than 50% of the time) engaged in structured fasting (i.e., not regularly fasting for ≥12hr/night) for the past 3 months.
• Not consuming a Mediterranean diet by not meeting 2 or more out of the following 3 Mediterranean eating pattern goals in the prior 3 months: ≥3 servings of vegetables per day, ≥ 3 servings of beans and legumes per week, or ≥ 1 serving of nuts per day.
  • Mediterranean diet will be screened with select components of a Mediterranean Diet Adherence Screener (MEDAS).
• Internet access on a smart phone, tablet, or computer.
• Willing to be randomized to a prolonged overnight fasting and guided Mediterranean dietary intervention or waitlist-control group.