Combined CM and STN Stimulation for Motor Epilepsy

Korábbi kezelés

• 2) Previous diagnosis of psychogenic/non-epileptic seizures.
• 3) Brain lesion resection or ablation surgery performed less than 6 months.

Más betegség

• 1) Non Motor Epilepsy.

Egyéb

• 4) Implanted Vagus nerve stimulation (VNS) or responsive neurostimulation (RNS) devices recommended neither stimulation off the device at least 6 months nor remove the device.
• 5) Pregnant, breastfeeding, or having the intention to become pregnant during the study period (for females of childbearing potential).

• 1) 18-65 Years.
• 2) Drug Resistant Epilepsy.
• 3) Motor Epilepsy - defined as:
  • Epilepsy diagnosis meeting ILAE criteria
  • Motor Epilepsy defined as including one or more of:
  • Tonic, Clonic, or Tonic-Clonic activity; ii. Myoclonic Jerks; iii.Epileptic Spasms; iv.Focal Motor Seizures (identified primary lesion will be in motor functional area, such as primary motor cortex (BA4), pre-motor cortex (BA6), Central Posterior Gyrus (BA1-3), or other motor region); v.Motor activity not secondary to non-motor seizure. c.Clinical or Electrographic corroboration of at least one of: i.Video-EEG confirmation of motor seizure semiology; ii.Interictal or ictal EEG findings consistent with epileptic motor network involvement; iii.Consistent clinical description by trained cliniciants.
• 4) >3 Focal or Generalized seizures / month with an inter-seizure interval no great than 30 days.
• 5) Subject or caregiver is able to provide epileptic seizure record within 90 days prior to the surgery.
• 6) Voluntarily participate in the trial, sign the informed consent form, and be willing to comply with study requirements, including follow-ups.