Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure

Korábbi kezelés

• Listed for transplant, and anticipated transplant listing or LVAD placement in the next 6 months
• Pregnancy or breastfeeding. A pregnancy test will be obtained from females of child-bearing potential at the screening visit or day 1 (prior to the receipt of IMT). Patients with a positive pregnancy test will be excluded. A negative result will be required for subjects who are females of child-bearing potential to receive IMT treatment. Patients will be counseled to avoid pregnancy which is the standard of care for patients with CHF.
• Patients on immunosuppressants (calcineurin inhibitors, prednisone ≥ 20 mg/day, methotrexate, azathioprine, immunosuppressive biologics, JAK inhibitors).
• Patients receiving cancer chemotherapy, immunotherapy, or radiation

Más betegség

• Clinically active inflammatory bowel disease
• History of celiac disease
• Renal disease requiring dialysis
• History of solid organ or bone marrow transplant
• Anticipated recurrent antibiotic use (patients with frequent urinary tract infections or sinusitis)
• History of severe anaphylactic food allergy

Laborértékek

• Patients with neutropenia (an absolute neutrophil count < 0.5 x 109 cells/L) obtained on a complete blood count with differential at screening

Egyéb

• Dysphagia to pills
• Acute myocarditis
• Infiltrative and hypertrophic cardiomyopathies
• Life expectancy of < 6 months
• Presence of ileostomy or colostomy

• Diagnosis of Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Reduced Ejection Fraction (HFpEF), New York Heart Association Class II-IV
• On stable treatment for CHF for one month prior to enrollment
• Able to swallow capsules
• Able to provide blood sample and fecal sample
• Stated willingness to comply with all study procedures and availability for the duration of trial to follow-up by telephone, in-person, email, and/or video visits or correspondence.