Gut, Immune, and Vascular Health in Metabolically Healthy Obesity

Korábbi kezelés

• Regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs three days prior to the study visit.
• Use weight-loss drugs (e.g., Ozempic, Wegovy).
• Have had any surgery that alters the stomach/gastrointestinal tract (e.g., gastric sleeve, gastric bypass).
• Use tobacco products or any illicit drugs.

Más betegség

• Have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
• Have been diagnosed with a chronic inflammatory or gastrointestinal condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
• Have dietary restrictions prohibiting consumption of the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies).

Laborértékek

• Use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin), or anti-hypertensive drugs.

Életkor

• Not 18-55 years old.

Egyéb

• BMI is not 18.5-24.9 kg/m2 or >30kg/m2 (part 1). BMI is not > 30 kg/m2 (part 2)
• Pregnant or expecting to become pregnant (females only).
• Postmenopausal (females only).
• Do not have 0-1 risk factors based on blood pressure, blood sugar, triglycerides, and HDL-cholesterol ("good cholesterol").
• Have taken antibiotics or probiotics in the last month.
• Have a pacemaker.
• Not able to stay in the supine position in the dark for at least 10 minutes (related to vascular measurements)

• 18-55 years old.
• BMI is 18.5-24.9 kg/m2 or >30kg/m2 (part 1). BMI > 30 kg/m2 (part 2)
• Not pregnant or expecting to become pregnant (females only).
• Not postmenopausal (females only).
• Have 0-1 risk factors based on blood pressure, blood sugar, triglycerides, and HDL-cholesterol ("good cholesterol").
• Have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
• Have not been diagnosed with a chronic inflammatory or gastrointestinal condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
• Do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs three days prior to the study visit.
• Have not taken antibiotics or probiotics in the last month.
• Do not use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin), or anti-hypertensive drugs.
• Do not use weight-loss drugs (e.g., Ozempic, Wegovy).
• Have not had any surgery that alters the stomach/gastrointestinal tract (e.g., gastric sleeve, gastric bypass).
• Do not use tobacco products or any illicit drugs.
• Do not have a pacemaker.
• Do not have dietary restrictions prohibiting consumption of the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies).
• Able to stay in the supine position in the dark for at least 10 minutes (related to vascular measurements)