Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery

Korábbi kezelés

• Patients who have received β-blockers within 30 days prior to screening.

Más betegség

• Patients with active infectious diseases, autoimmune diseases (including specific rheumatic diseases), coagulation disorders, or cardiovascular diseases other than hypertension or angina pectoris.
• Patients with moderate to severe asthma or chronic obstructive pulmonary disease (COPD).
• Patients with a history of malignancy within the past 5 years.
• Patients with systolic blood pressure < 100 mmHg or heart rate < 55 beats per minute.

Laborértékek

• Patients with clinically significant hepatic, hematologic, or renal dysfunction, defined as any of the following:
  • ① ANC <1,500/mm3
  • Platelets <100,000/mm3
  • Hb <9 g/dL
  • AST and ALT > 2.5 x upper limit of normal (ULN) ⑤ Alkaline phosphatase > 2.5 x ULN ⑥ Total bilirubin > 1 x ULN ⑦ Serum creatinine >1.5 x ULN or estimated creatinine clearance < 60 mL/min (as calculated using the method standard for the institution)

Egyéb

• Patients with distant metastases.
• Patients who are pregnant or breastfeeding at the time of enrollment.
• Patients for whom data collection is considered difficult at the discretion of the investigator.
• Patients who are unable to understand or complete study questionnaires.

• Female patients aged 20 to 70 years.
• Patients diagnosed with hypertension or angina who require medication.
• Patients diagnosed with unilateral, resectable primary breast cancer (ICD-10: C50), Stage I-III.
• ECOG performance status of 0-1.
• Patients scheduled to receive standard postoperative treatment (including adjuvant radiotherapy
• Patients who voluntarily decide to participate and sign the written informed consent form