Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells

Korábbi kezelés

• Any regular immunosuppressive treatment [Inhaled or topical steroids are permissible]
• Vaccine within 4 weeks prior to screening

Más betegség

• Critical left main stem coronary disease
• Severe valvular disease (for example 'severe' aortic stenosis as classified on echocardiogram report)
• Haemodynamic instability caused by arrhythmia requiring cardioversion in the current admission
• Autoimmune disease
• Allergy or intolerance to aldesleukin
• Signs and symptoms of active infection
• History of human immunodeficiency virus (HIV), hepatitis B or C
• Current malignancy requiring active treatment
• Clinically relevant medical or surgical conditions that, in the opinion of the investigator, would put the subject at risk by participating in the study

Laborértékek

• Known active hepatic disease or alanine aminotransferase (ALT) > 3xULN
• Severe chronic kidney disease (defined as eGFR < 30 ml/min/1.73m2)

Életkor

• Women of child-bearing potential and pregnancy (women must be either postmenopausal (defined as being amenorrhoeic for greater than 2 years with an appropriate clinical profile (e.g. age appropriate (>55 years old), history of vasomotor symptoms) or having documented hysterectomy and/or bilateral oophorectomy)

Egyéb

• Non-sustained ventricular tachycardia of >10 beats in the last 48 hours
• Women who are breast-feeding

• Aged over 18 years old
• Undergoing CABG surgery