tDCS for Late-Life Depression

Korábbi kezelés

• contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;
• neuromodulation treatment including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), tDCS, or vagus nerve stimulation (VNS) within the past six months;
• concurrent use of medications that substantially lower seizure threshold;

Más betegség

• contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;
• depressive disorder due to a medical condition;
• history of seizures or epilepsy;
• bipolar disorder;
• psychotic disorders;
• severe personality disorder;
• active substance use disorder within the past six months or history of substance induced mood or psychotic disorder;
• a clinically established diagnosis of dementia as reported in the participant's health record or scoring 1 or above on CDR;

Egyéb

• Participants meeting any of the following criteria will be excluded:
• psychotic depression;
• active suicidal ideation with plan or intent requiring a higher level of care;
• pregnancy;
• medically unstable in the clinical opinion of the principal investigators.

• Participants must meet all of the following criteria:
• age 60 years or older;
• diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Structured Clinical Interview for DSM-5 (SCID-5);
• score of 16 or higher on the Quick Inventory of Depressive Symptomology-Clinician Rated (QIDS-C) at screening;
• stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;
• willingness and capacity to provide informed consent;
• Clinical Dementia Rating scale of 0 or 0.5.
• availability of an informant who has sufficient knowledge of the participant's daily functioning as ascertained by the study team.