Endothelin Role In COronary Microcirculation

Korábbi kezelés

• Known significant coronary artery disease, defined as previous investigations demonstrating greater than 50% epicardial coronary artery stenosis.
• Uncontrolled hypertension, defined as clinic blood pressure greater than 140/90 mmHg despite treatment with three or more antihypertensive medications.
• Previously documented allergy or hypersensitivity to endothelin receptor antagonists.
• Concurrent use of medications contraindicated with endothelin receptor antagonist therapy.

Más betegség

• Symptoms consistent with unstable angina, including:
• Angina at rest lasting more than 20 minutes.
• New-onset severe angina.
• Angina increasing in frequency, duration, or occurring at a lower threshold.
• Angina occurring following a recent myocardial infarction.
• Severe heart failure or symptoms of active heart failure.
• Clinical evidence of active infection at the time of recruitment.
• Significant liver disease, defined as Child-Pugh Class B or C liver disease (or worse than Child-Pugh Class A).
• Requirement for invasive coronary angiography for another clinical indication, including but not limited to valvular heart disease assessment or intervention.

Laborértékek

• Significant chronic kidney disease, defined as estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m².

Egyéb

• Pregnancy or breastfeeding.
• Poorly controlled asthma as defined in the study protocol.
• Systolic blood pressure less than 90 mmHg at the time of recruitment.

• Clinical diagnosis of symptomatic angina, defined as the presence of substernal chest pain or discomfort provoked by exertion or emotional stress and relieved by rest and/or glyceryl trinitrate (nitroglycerin).
• Age 18 years or older.
• Able and willing to provide written informed consent.
• Able and willing to adhere to study procedures and follow-up requirements.