Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus

A regiszterben nem jelölt feltételek

• Inclusion criteria:
  • For patients :
  • Child or adolescent with newly diagnosed ITP or SLE according to the specific definitions of ITP or SLE, prior to any treatment,
  • Over 1 and under 18 years of age at diagnosis, weighing more than 7 kg.
  • Written consent from parents or guardians,
  • Patient affiliated to a social security scheme.
  • For controls :
  • Over 1 and under 18 years of age at diagnosis, weighing more than 7 kg.
  • Follow-up in the day hospital at the Bordeaux University Hospital, for a condition that does not affect the immune system
  • Matched on age,
  • Written consent from parents or guardians,
  • Patient affiliated to a social security scheme
• Exclusion criteria:
  • For patients :
  • ITP secondary to a known cause: previous or concomitant immune deficiency, bone marrow or organ transplantation, other autoimmune disease, Evans syndrome (autoimmune hemolytic anemia or autoimmune neutropenia present at ITP diagnosis) or cancer with immunosuppressive therapy.
  • Treatment with immunomodulation or immunosuppressants (including immunoglobulins, corticoids, hydroxychloroquine), started prior to inclusion (day of sampling).
  • Pregnant women, women in labour and breastfeeding women
  • For controls :
  • Suffering from an immunological disease,
  • Infection within fifteen days prior to inclusion,
  • Immunomodulatory therapy.
  • Pregnant women, women in labour and breastfeeding women