Spinal Cord Stimulation Combined With Motor Imagery Brain-Computer Interface for Chronic Post-Stroke Upper Limb Motor Dysfunction

Korábbi kezelés

• Previous neuromodulation surgery for hemiparesis, such as spinal cord stimulation or deep brain stimulation.

Más betegség

• Other neurological diseases that may cause motor dysfunction, such as Parkinson's disease, multiple sclerosis, or spinal cord injury.
• Severe visual or auditory impairment that prevents cooperation with visual or auditory feedback instructions of the brain-computer interface system.
• Contraindications to spinal cord stimulation surgery, such as severe coagulation dysfunction, infection at the puncture site, severe spinal deformity, or spinal canal stenosis.
• History of epilepsy, intracranial metal implants, cardiac pacemaker, or other contraindications to magnetic resonance imaging.
• Any other condition judged by the investigator to make the participant unsuitable for this study.

Egyéb

• Pregnancy or lactation.

• Age 18 to 75 years.
• First-ever unilateral supratentorial stroke, either ischemic or hemorrhagic, confirmed by computed tomography or magnetic resonance imaging, resulting in hemiparesis, with disease duration longer than 6 months.
• At least one active movement in the wrist or fingers of the affected upper limb, with muscle strength of grade 1 or higher.
• Fugl-Meyer Assessment for Upper Extremity score between 10 and 40, indicating moderate upper limb motor impairment.
• Change in Fugl-Meyer Assessment score less than 10% within the previous month, indicating a functional plateau.
• Clear consciousness and basically normal cognitive function, with Mini-Mental State Examination score of 24 or higher.
• Stable clinical condition and ability to understand and cooperate with simple instructions and rehabilitation training.
• Written informed consent voluntarily signed by the participant or legal guardian.