Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)
Key facts
- Where
- Seoul, Dél-KoreaSee the site
Where in Dél-Korea
- Samsung Medical CenterSeoul, Dél-KoreaToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Samsung Medical Center
- Trial code
- NCT07726901
- Record updated
- 2026. július 24.
- Original description
This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.Read full original descriptionShow less
This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.
Participants will be randomized 1:1 into either the Anatomy-based group or the Emphasize map-guided group
* Anatomy-based group : Pulmonary vein isolation (PVI) using pulsed-field ablation (PFA) with a single-shot multielectrode catheter. * Emphasize map-guided group : PVI using radiofrequency (RF) ablation followed by additional EnSite X-guided pathologic substrate modification.
Participants will be followed for 1 year to compare the incidence of any atrial tachyarrhythmia and other clinical parameters between the two groups.
Inclusion: Adults aged 19 years or older who have voluntarily provided written informed consent to participate in the study; Patients diagnosed with persistent atrial fibrillation (AF) who are scheduled to undergo catheter ablation for AF.
Exclusion: History of prior catheter ablation or MAZE surgery for atrial fibrillation; History of prior open-heart surgery; Patients with end-stage renal disease (ESRD); Heart failure corresponding to New York Heart Association (NYHA) functional class IV; Acute coronary syndrome (ACS) experienced within the past 3 months; Patients with terminal illness and a life expectancy of less than one year; Any other condition that the investigator deems inappropriate for participation in the study; Left atrial (LA) diameter exceeding 60 mm; Women who are pregnant, lactating, or of childbearing potential.