Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress

Más betegség

• Active psychosis or carry a diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder mixed, or bipolar disorder with a history of psychotic episodes
• Current substance use disorder or significant history of substance abuse
• Unstable vital signs, including moderate or severe hypertension that is not controlled with medication
• History of an adverse reaction to ketamine or esketamine
• Any condition that, in the clinical opinion of the investigator, impairs capacity to provide informed consent (including but not limited to: seizure disorders, psychiatric conditions, neurological conditions, intellectual disabilities, neurodegenerative disorders, renal impairment, hepatic impairment, bleeding disorders, cardiovascular disease, pulmonary disease, or recent history of stroke, aneurysm, or malignancy).
• Any condition that, in the clinical opinion of the investigator contraindicates intramuscular injections (including but not limited to: current medications, current or recent infection, neuromuscular conditions, skin conditions, bleeding disorders, cardiovascular disease, ror recent myocardial infarction).
• Any condition that, in the clinical opinion of the investigator that contraindicates ketamine (including but not limited to: seizure disorders, psychiatric conditions, neurological conditions, intellectual disabilities, neurodegenerative disorders, renal impairment, hepatic impairment, bleeding disorders, cardiovascular disease, pulmonary disease, or recent history of stroke, aneurysm, or malignancy).

Életkor

• Patients under the age of 18

Egyéb

• Pregnant individuals (Individuals of child-bearing potential will be given a pregnancy test)
• Individuals whose current ED visit was due to a suicide attempt defined by "actual attempt" on the C-SSRS and which resulted in a score greater than zero on the Lethality/Potential Lethality/Medical Damage C-SSRS questions.
• Pregnant individuals
• Individuals who were participants in the Dosing Cohort

• Admitted to the Evanston Hospital ED and met criteria for SCS
• Awaiting voluntary admission to the Evanston Hospital inpatient psychiatric unit
• Above the age of 18.
• Ability to provide written informed consent.
• Admitted to the Evanston Hospital ED
• Assessed for Suicidal Ideation by the Crisis Team
• Over the age of 18