The Effect of Additive On-Demand Sildenafil vs. Dextrose Candy on Maximum Exercise Capacity in Pulmonary Arterial Hypertension

Korábbi kezelés

• Other clinically significant concomitant disease states (e.g., severe renal or hepatic disease, unstable cardiovascular disease, etc.)
• Concurrent medication with:
  • Nitric oxide donors (molsidomine, nicrorandil, etc.)
  • Soluble guanylate cyclase stimulators (riociguat)
  • Potent CYP3A4 inhibitors (azoles, clarithromycin, protease inhibitors)
• Participation in another study with investigational drug with potential influence the study data within the 30 days preceding and during the present study.

Más betegség

• Moderate-to-severe chronic obstructive or restrictive pulmonary disease (FEV1 ≤ 60% predicted, FVC ≤ 60% predicted)
• History of anterior ischemic optic neuropathy or hereditary retinal disease
• Known allergies or hypersensitivity to sildenafil 20mg (Revatio 20mg) or dextrose candy (Dextroenergy) including any of its components

Egyéb

• Severe resting hypoxia (PaO2 <7.3 kPa)
• Women with known pregnancy or breast feeding

• Signed Informed consent
• Age 18 - 80 years (both sexes)
• Pulmonary hypertension (PH) class I (PAH) previously diagnosed according to ESC/ERS 2022/2019 guidelines (mPAP ≥ 20 mmHg, PVR ≥ 2 WU, PAWP ≤ 15 mmHg) during diagnostic right-heart catheterization.
• Stable condition, on the same PH-medication for >4 weeks