Fibroblast Activating Protein (FAP) PET/CT in Adults With Tuberculosis

Korábbi kezelés

• Have been administered at least 7 days of corticosteroids or any duration of another systemic investigational agent within 3 months of enrollment per medical record review or patient self-report

Más betegség

• Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study, including completion of the study follow-up or TB treatment.
• History of major alternative pulmonary disease such as asthma, chronic obstructive pulmonary disease (COPD), or interstitial lung disease as per medical record review or patient self-report. "Major" is defined as potentially resulting in pulmonary radiographic abnormalities that could interfere with interpretation of PET-CT scan data.

Egyéb

• Diagnosed with TB that is resistant to rifampin per medical record review or have only extrapulmonary TB.
• Women of childbearing potential may not be pregnant or breast-feeding. A negative pregnancy test will be required before [F-18]-FAPI-74 injection.
• Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
• Have symptoms or signs that, in the opinion of the investigative team, are suggestive of active TB at the time of pre-screening per patient self-report

• Participants will be ≥ 21 years of age
• Diagnosed with microbiologically confirmed (culture or Xpert MTB/RIF PCR positive on at least one respiratory sample) pTB
• Be currently on or able to initiate standard drug-sensitive pTB treatment according to IDSA guidelines.
• Have initiated or planning to initiate TB treatment prior to screening and enrollment.
• Have a Timika CXR score indicating cavitary disease
• Be able and willing to provide written informed consent to participate in the study