Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)

Más betegség

• Pre-existing neurological disability or pre-injury condition that would have resulted in a Glasgow Outcome Scale-Extended (GOS-E) score <8 if assessed before the injury.

Egyéb

• High risk of loss to follow-up, including patients without a reliable phone, those experiencing homelessness, those who are incarcerated, or those who are wards of the state.
• Pregnancy at the time of enrollment.
• Inability to speak English or Spanish, which would prevent completion of the required assessments.

• Diagnosis of mild traumatic brain injury (TBI), as defined by the 2023 American Congress of Rehabilitation Medicine (ACRM) criteria.
• Enrollment within 24 hours of injury.
• Glasgow Coma Scale (GCS) score of 15 at emergency department (ED) enrollment.
• Consent to study procedures, including:
  • Blood collection for biomarker measurement, including glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1).
  • Continuous use of a health-monitoring device for 3 months.
  • Follow-up assessments by telephone at 14 days and 90 days.
  • Completion of a daily symptom inventory via WHOOP/smartphone.