Post-exercise Blood Pressure With Inorganic Nitrate

Korábbi kezelés

• Has experienced significant weight loss ~3 kg in the last three months or taking any weight loss drugs
• Currently on hormone replacement of any kind
• Oral antibiotic use within previous four weeks including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use

Más betegség

• Current medical condition that prohibits exercising at high intensities
• History of medical conditions that would prohibit high intensity exercise, such as:, uncontrolled hypertension (≥140/90), diabetes, myocardial infarction, cerebrovascular event, known cardiovascular, pulmonary, renal, metabolic diseases, and acute or unstable disease other than high BMI and waist circumference
• Oral cancer/severe oral disease

Laborértékek

• Currently taking or have taken any of the following medications in the last 4 weeks (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g., Cialis, Viagra), or xanthine oxidase inhibitors (e.g., Allopurinol))

Egyéb

• Body mass index ≤ 29.9 Kg/m2
• Smoker within last 5 years
• Current injuries that would prohibit exercising on a stationary bike
• Currently restricted by medical doctor to engage in exercise
• Had hysterectomy or oophorectomy
• Pregnant women or planning to be pregnant, Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants

• Willingness and ability to comply with scheduled visits and study procedures.
• Males and females, ages 18-40 years old
• Sedentary (<150 minutes of moderate intensity aerobic exercise per week, or not engaged in a regular exercise program at all
• Resting systolic BP ≥ 120 mmHg.
• BMI ≥ 30 kg/m2
• Waist circumference ≥94 cm for males and ≥80 cm for females
• Be able to perform exercise on a cycle ergometer without assistance
• Stable medication regimen for the last 6 months
• Be able to discontinue the use of inorganic nitrate rich foods such as beets, arugula, spinach, celery, and grapefruit throughout the duration of the study.