Clinical Significance of Internal Carotid Artery Dolichoarteriopathy

Korábbi kezelés

• Acute ischemic or hemorrhagic stroke within 6 months before planned enrollment if the participant's condition prevents valid baseline assessment or study procedures.
• Myocardial infarction within the previous 3 months.

Más betegség

• Unstable angina, NYHA class III-IV heart failure, or another decompensated cardiovascular condition that prevents safe participation.
• Severe cognitive impairment or dementia preventing valid informed consent or neuropsychological assessment, unless participation is legally permitted through an authorized representative.
• Active malignancy or systemic treatment expected to substantially affect the investigated biomarkers or prognosis.
• Decompensated respiratory, renal, or hepatic disease that may substantially affect safety or interpretation of study results.
• Psychiatric disorder or other condition preventing adequate communication or adherence to the study protocol.

Egyéb

• Complete occlusion of the study internal carotid artery or brachiocephalic trunk that prevents valid assessment of the pathophysiological role of arterial tortuosity.
• Hemodynamically significant atherosclerotic stenosis of the internal carotid artery greater than 50% on the side relevant to the analysis when it represents the dominant alternative cause of impaired blood flow.

• Age 18 to 75 years, inclusive.
• Verified pathological deformation of the internal carotid artery, including tortuosity, kinking, and/or coiling, confirmed by duplex ultrasound and/or angiographic imaging.
• Ability to undergo baseline clinical and neurological assessment and longitudinal follow-up.
• Written informed consent for participation and processing of personal data. Separate optional consent may be obtained for storage of residual biospecimens and genetic testing, where applicable.