N-Acetylcysteine for Bipolar and Alcohol Use Disorders

Korábbi kezelés

• Concomitant use of nitroglycerin, carbamazepine, or another medication deemed hazardous with NAC.
• Concomitant use of specified alcohol-use-disorder medications or medications that could interfere with glutamate transmission.
• Electroconvulsive therapy in the past 3 months.
• Medication dose change of 20% or greater within 2 weeks before testing.
• NAC use in the last month or prior adverse effects from NAC.
• Significant claustrophobia or prior negative experience with MRI.

Más betegség

• Primary psychiatric diagnosis other than bipolar disorder.
• Uncontrolled neurological condition that could confound study results.
• History of brain injury with loss of consciousness greater than 5 minutes.
• History of intellectual disability or dementia.
• Uncontrolled medical condition that may adversely affect study conduct or participant safety.
• Hepatocellular disease as defined in the protocol.
• Renal insufficiency as defined in the protocol.
• Has an allergy to riboflavin

Egyéb

• Pregnancy, lactation, or refusal to use adequate contraception when applicable.
• Current suicidal or homicidal risk.
• Baseline MADRS score greater than 35 or YMRS score greater than 25.
• Clinically significant alcohol withdrawal symptoms or autonomic instability.
• Non-MRI-safe material in the body.

• Age 18 to 60 years.
• Meet DSM-5 criteria for bipolar I or bipolar II disorder.
• Prescribed daily use of at least one FDA-approved mood-stabilizing medication (lithium, divalproex sodium, lamotrigine, or a second-generation antipsychotic).
• Meet DSM-5 criteria for current, within the past 90 days, moderate to severe alcohol use disorder.
• Active alcohol use in the past 14 days, with heavy drinking days on at least 50% of drinking days in the past 30 days.
• Able to provide informed consent and read, understand, and accurately complete assessment instruments.
• Willing to commit to medication treatment and follow-up assessments.
• Willing to abstain from antioxidant supplements for the duration of the study.