NCT07923513Toborzás még nem indult
Compulsive Eating and Brain's Reward System in Different Pathologies
Bipolar Disorders, Parkinson's Disease, ObesiTy and Compulsive eAting: TransnosOlogical Assessement of the Brain's Reward System
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. nov. 6.
Rövid összefoglaló (regiszter, angolul)
Compulsive eating behaviors represent a significant issue across various disorders such as Parkinson's disease, bipolar disorders, and obesity. Despite their apparent differences, these conditions share common underlying disturbances involving the brain's reward system, particularly within dopaminergic networks.6,7 Previous neuroimaging studies have consistently reported reward system connectivity impairment associated with compulsive eating, in each of these disorders. However, few studies have simultaneously explored the neurobiological similarities and specificities of this common symptom, eating behavior, when occurring in different populations and disorders. The Bi-POTATOS project proposes an original and innovative approach by adopting a transdiagnostic perspective, employing brain imaging and comprehensive psycho-behavioral assessments to investigate common behavioral characteristics and neural circuit alterations associated with compulsive eating across these three conditions. For the first time, this study will allow a direct comparison of the cerebral signatures linked to compulsive eating behavior, clearly distinguishing between transdiagnostic vulnerabilities and features unique to each clinical condition. The central hypothesis is that similar dysfunctions in brain regions involved in motivation and impulsive decision-making underpin compulsive eating behaviors, irrespective of the initial diagnosis. However, the underlying pathology may modulate these mechanisms, introducing certain specificities. By clarifying these common mechanisms, the Bi-POTATOS project will not only enhance our understanding of the neurobiological etiology of these disorders but also pave the way for innovative, targeted therapeutic interventions. This project will precisely identify whether specific neural alterations constitute a universally relevant therapeutic target, or conversely, determine which alterations necessitate tailored therapeutic strategies based on the underlying pathology.
- Állapot (regiszter)
- Toborzás még nem indult
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 150 (tervezett)
- Első benyújtás
- 2026. júl. 27.
- Kezdés
- 2026. dec.
- Elsődleges befejezés
- 2029. júl.
- Fő szponzor
- University Hospital, Clermont-Ferrand
- Betegségek
- Elhízás, Bipoláris zavar, Parkinson-kór
- NCT-szám
- NCT07923513
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Tervezett résztvevők: 150
- 2026. dec. és az elsődleges befejezés (2029. júl.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
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Korábbi kezelés
- Treated with deep brain stimulation
- Treated with deep brain stimulation or vagus nerve stimulation
Más betegség
- Dementia (MoCA <22)
- History of stroke or brain trauma that may impact MRI findings
- Patient suffering from psychiatric disorder
- Suffering from progressive neurological pathology and psychiatric disorder
- History of bariatric surgery
- Suffering from neurological pathology and psychiatric disorder other than bipolar disorder
Egyéb
- 1-Common Criteria
- Severe depression (Beck Depression Inventory>30)
- Contraindications to MRI (implanted stimulator, insulin pump, intraocular metallic foreign bodies or close to the nervous and vascular systems, claustrophobia, non-removable dental appliance, tattoo on the face or neck, …)
- Refusal to be informed in case of incidental finding on MRI
- Patients under guardianship, deprived of freedoms or protection of justice.
- Pregnant women, breastfeeding women
- 2- Specific criteria
- Parkinsonian patients:
- People suffering from neurological pathologies other than PD
- Patients with severe tremor (> 3 for a tremor sub-item of the MDS-UPDRS III) or excessively severe dyskinesia contraindicating MRI
- Obese patients:
- Weight >220kg contraindicating MRI
- Body (Shoulder) diameter > 220 cm contraindicating MRI
- GLP1 treatment
- Bipolar patients:
- Current acute depressive or hypomanic episode according to DSM 5
- Electroconvulsivotherapy < 6 months
Kiket keres a vizsgálat
- 1-Common Criteria (Parkinson disease, Obesity, Bipolar patients)
- Men or women, right-handed, 18 to 80 years old
- With or without compulsive eating according to the QEWP-R
- No changes to long-term treatments in the previous month
- Cooperation and understanding to strictly comply with the conditions set out in the protocol
- Acceptance of the protocol and signing of a written informed consent
- Affiliation to the social security system
- 2-Specific criteria Parkinsonian patients (n=25 with CE, n=25 without CE)
- Diagnosis of Parkinson's disease according to the Movement Disorders Society criteria
- BMI<30
- Obese patients (n=25 with CE, n=25 without CE)
- Obese patients according to HAS 2022 classification
- BMI≥30
- Bipolar patients (n=25 with CE, n=25 without CE)
- Diagnosis of bipolar disorder according to DSM 5 criteria
- BMI<30
Életkor a regiszterben: 18 év – 80 év · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| CHU de Clermont-Ferrand Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát | Clermont-Ferrand | Franciaország | Ismeretlen állapot |
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