Individualized Temporal Interference Stimulation for Reward Processing in Late-Life Depression
Key facts
- Where
- Hefei, KínaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Forrás: NCT07925047: ki vehet részt
Where in Kína
- Hefei Fourth People's HospitalHefei, KínaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing HuiLongGuan Hospital
- Trial code
- NCT07925047
- Record updated
- 2026. november 9.
- Original description
This study aims to investigate the effects and neural mechanisms of individualized temporal interference stimulation (TI) targeting the left nucleus accumbens in older adults with depression. A total of 70 participants aged 60-80 years will be randomly assigned to receive active TI or sham stimulation. Clinical and cognitive assessments, a probabilistic reversal learning (PRL) task, MRI, and TMS-EEG will be used to evaluate changes in depressive symptoms, reward processing, and brain activity. Clinical and cognitive follow-up assessments will be conducted at 1 and 4 weeks after the intervention.Read full original descriptionShow less
Neural Mechanisms Underlying the Modulation of Reward Processing by Individualized Temporal Interference Stimulation Targeting the Nucleus Accumbens in Late-Life Depression
This study aims to investigate the effects and neural mechanisms of individualized temporal interference stimulation (TI) targeting the left nucleus accumbens in older adults with depression. A total of 70 participants aged 60-80 years will be randomly assigned to receive active TI or sham stimulation. Clinical and cognitive assessments, a probabilistic reversal learning (PRL) task, MRI, and TMS-EEG will be used to evaluate changes in depressive symptoms, reward processing, and brain activity. Clinical and cognitive follow-up assessments will be conducted at 1 and 4 weeks after the intervention.
Inclusion: Aged 60-80 years; Meet the DSM-5 diagnostic criteria for a current episode of major depressive disorder (MDD); Have at least moderate depressive symptoms; Able to understand and comply with study procedures, provide written informed consent, and voluntarily participate in the study.
Exclusion: History of severe neurological disorders or epilepsy; Severe or unstable medical conditions; Comorbid severe psychiatric disorders, such as bipolar disorder or schizophrenia; Significant cognitive impairment that interferes with informed consent or completion of study procedures; Any other medical or safety condition that, in the investigator's judgment, makes participation inappropriate; Contraindications to MRI, transcranial magnetic stimulation (TMS), or transcranial electrical stimulation; High suicide risk.