Targeted Minimally-Invasive Glaucoma Surgery
Megadott ok: insufficient effect size at planned interim analysis
Key facts
- Where
- Linz, AusztriaSee the site
Where in Ausztria
- Kepler University Hospital, Johannes Kepler UniversityLinz, AusztriaNo longer taking part
Trial details
- Who runs it
- Johannes Kepler University of Linz
- Trial code
- NCT07927803
- Record updated
- 2026. november 10.
- Original description
MIGS procedures are currently performed without targeting a specific region of the outflow pathway. The temporal surgical approach means that treatment is delivered to the nasal quadrant. Preclinical analyses have shown that targeted treatment of low-flow regions of the trabecular meshwork can improve efficacy. The aim of this study is to use aqueous angiography to guide the placement of an established MIGS procedure, excimer laser trabeculostomy (ELT; Elios Vision GmbH), in order to improve its efficacy.Read full original descriptionShow less
Angiographie Gezielte MIGS Chirurgie: Translationales Pilotprojekt
MIGS procedures are currently performed without targeting a specific region of the outflow pathway. The temporal surgical approach means that treatment is delivered to the nasal quadrant. Preclinical analyses have shown that targeted treatment of low-flow regions of the trabecular meshwork can improve efficacy. The aim of this study is to use aqueous angiography to guide the placement of an established MIGS procedure, excimer laser trabeculostomy (ELT; Elios Vision GmbH), in order to improve its efficacy.
Inclusion: age equal to or above 45 years; written informed consent; Cataract with indication for surgery; preperimetric to moderate open-angle glaucoma; central corneal thickness 480-620µm; availability, willingness and ability to understand and give consent to study participation.
Exclusion: previous glaucoma surgery; previous selective laser trabeculoplasty; ocular hypertension; inflammatory ocular disease; increases risk for intraoperative floppy iris syndrome; participation in another interventional study; ambiguous glaucoma diagnosis; corneal pathology with influence on intraocular pressure measurement; medical interventions planned in parallel, that interfere with the study intervention.