Effects of Adjunctive Melatonin Gel in Type II Diabetics With Stage III-IV Periodontitis
Key facts
- Where
- New Cairo, EgyiptomSee the site
Where in Egyiptom
- Badr University in CairoNew Cairo, EgyiptomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Badr University
- Trial code
- NCT07928752
- Record updated
- 2026. november 10.
- Original description
The goal of this clinical trial is to learn if melatonin gel works to treat deep periodontal pockets in diabetic patients with periodontisits.Read full original descriptionShow less
Effects of Adjunctive Melatonin Gel With Minimally Invasive Non-Surgical Therapy on Clinical Outcomes, Inflammatory Biomarkers and Glycemic Control in Type II Diabetics With Stage III-IV Periodontitis: A Randomized Controlled Clinical Trial
The goal of this clinical trial is to learn if melatonin gel works to treat deep periodontal pockets in diabetic patients with periodontisits.
The main question it aims to answer is:
Does melatonin gel when used with minimal invasive non surgical periodontal therapy show better healing effects.
Inclusion: Male and female participants. Patients diagnosed with Stage III / IV periodontitis. Presence of at least one site with probing pocket depth (PPD) ≥ 5 mm and clinical attachment loss consistent with Stage III/ IV periodontitis; Subjects with glycated hemoglobin higher than 6.5% were defined as diabetic.
Exclusion: Smokers: current or former, as smoking impairs periodontal healing capacity and response to periodontal treatments; Pregnancy and lactation due to ethical considerations and potential hormonal influences on periodontal tissues; Patient who received periodontal therapy within the previous 6 months. Use of antibiotics, anti-inflammatory drugs, or antioxidant supplement within the previous 6 months; Patient with systemic condition other than type 2 diabetes or medication that may affect periodontal healing.