Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.
What people read
Posts online say that CBD (cannabidiol) helps with Parkinson disease.
What has been studied
- 9In people9 randomised trials
- 8In animals
- 4Only in the lab
What the studies found
CBD (cannabidiol) has been tested in randomised trials in people with Parkinson disease.
We found 48 published papers on CBD (cannabidiol) and Parkinson disease. They were published between 2003 and 2026.
9 of them are studies in people (9 randomised trials), 13 are reviews, 8 are studies in animals and 4 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Cannabidiol and cognitive functions/inflammatory markers in Parkinson's disease: A double-blind randomized controlled trial at Buriram Hospital (CBD-PD-BRH trial).2025 · Parkinsonism Relat Disord · Randomised trial
- Short-Term Cannabidiol with Δ-9-Tetrahydrocannabinol in Parkinson's Disease: A Randomized Trial.2024 · Mov Disord · Randomised trial
- Cognitive Safety Data from a Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase IIb Study of the Effects of a Cannabidiol and Δ9-Tetrahydrocannabinol Drug on Parkinson's Disease-Related Motor Symptoms.2023 · Mov Disord · Randomised trial
- The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical Trial.2023 · Cannabis Cannabinoid Res · Randomised trial
- Cannabidiol-enriched cannabis extraction product in Parkinson's disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital.2022 · J Neurosci Rural Pract · Randomised trial
- Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder.2021 · Mov Disord · Randomised trial
- Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study.2020 · Cannabis Cannabinoid Res · Randomised trial
- Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease.2020 · J Psychopharmacol · Randomised trial
- Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.2014 · J Psychopharmacol · Study in people
- Cannabidiol and Parkinson's disease: Investigating receptor interactions and their therapeutic implications.2026 · Pharmacol Ther · Review
- CBD's potential impact on Parkinson's disease: An updated overview.2024 · Open Med (Wars) · Review
- A journey through cannabidiol in Parkinson's disease.2024 · Int Rev Neurobiol · Review
- Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders.2024 · Basic Clin Pharmacol Toxicol · Review
- Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation.2021 · Aging (Albany NY) · Review
- Emerging potential of cannabidiol in reversing proteinopathies.2021 · Ageing Res Rev · Review
- Neuroprotective effects of a cannabidiol nanoemulsion in a rotenone-induced rat model of Parkinson's disease: Insights into the gut-brain axis.2025 · Eur J Pharmacol · In animals
- Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.2023 · Neurochem Res · In animals
- Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease.2022 · Neurotoxicology · In animals
- Cannabidiol Alleviates the Damage to Dopaminergic Neurons in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease Mice Via Regulating Neuronal Apoptosis and Neuroinflammation.2022 · Neuroscience · In animals
- Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis.2022 · Evid Based Complement Alternat Med · In animals
- Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease.2021 · Int J Mol Sci · In animals
- Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity.2026 · Free Radic Biol Med · In the lab
- Chemical Profiling of Polyphenolic Fraction of Cannabis sativa L. vr. Kompolti Industrial Inflorescences: Insights into Cannabidiol Neuroprotective Effects in a Cellular Model of Parkinson's Disease.2025 · Plants (Basel) · In the lab
- Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway.2020 · Fitoterapia · In the lab
- The neuroprotection of cannabidiol against MPP⁺-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease.2015 · Toxicol In Vitro · In the lab
- Healthcare Providers' Acceptability of Cannabis And Cannabidiol to Manage Parkinson's Disease in France.2026 · Curr Ther Res Clin Exp · Other paper
- Acceptability of and attitudes to the therapeutic use of cannabis and cannabidiol in people with Parkinson's disease: A French survey.2024 · Clin Park Relat Disord · Other paper
- Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial.2024 · JMIR Dermatol · Other paper
- Cannabidiol and Tetrahydrocannabinol Use in Parkinson's Disease: An Observational Pilot Study.2023 · Cureus · Other paper