Stem cell treatment & Parkinson disease

Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.

What people read

Posts online say that Stem cell treatment helps with Parkinson disease.

What has been studied

• 7In people4 randomised trials
• 56In animals
• 10Only in the lab

What the studies found

!Stem cell treatment has been tested in randomised trials in people with Parkinson disease.

We found 240 published papers on Stem cell treatment and Parkinson disease. They were published between 2001 and 2026.

7 of them are studies in people (4 randomised trials), 141 are reviews, 56 are studies in animals and 10 are studies only in the lab. 2 papers were retracted.

The most important ones are listed under Sources.

Sources

1. Intranasal human neural stem cell therapy in early-onset Parkinson's disease with motor complications: A randomized, double-blind, placebo-controlled trial.2026 · Cell Transplant · Randomised trial
2. A pilot phase IIa randomized, placebo-controlled, double-blind trial of intravenous human pluripotent adipose-derived stem cells (PASCs) in Parkinson's disease: The REPOSE study.2026 · Cell Transplant · Randomised trial
3. Evaluation of Multiple Intravenous Infusions of Autologous Adipose-Derived Mesenchymal Stem Cells in Parkinson's Disease: A Randomized, Double-Blind Clinical Trial.2026 · Parkinsons Dis · Randomised trial
4. Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial.2025 · Mov Disord · Randomised trial
5. Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.2026 · Nat Med · Study in people
6. Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson's disease.2025 · Cell · Study in people
7. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson's disease models and patients.2024 · Mil Med Res · Study in people
8. The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies.2026 · Mol Neurobiol · Review
9. Emerging therapies expected to make a difference in Parkinson's disease management.2026 · Parkinsonism Relat Disord · Review
10. Neuroinflammation and Graft Survival in Pluripotent Stem Cell-Derived Therapies for the Central Nervous System.2026 · J Neurochem · Review
11. Dissecting divergent outcomes in stem cell-derived dopamine cell therapy trials for Parkinson's disease.2026 · Cell Stem Cell · Review
12. From neural loss to regeneration: modulating cell death to enhance pluripotent stem cell graft survival and integration.2026 · Cell Death Dis · Review
13. Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell-Based Therapy.2026 · J Neurochem · Review
14. Mesenchymal stem cells inhibit ferroptosis in dopaminergic neurons of Parkinson's disease mice by phosphorylating STAT6.2026 · Neural Regen Res · In animals
15. Dibucaine induces autophagic flux and reduces Ser129-phosphorylated α-synuclein in induced pluripotent stem cell-derived neurons with SNCA duplication.2026 · Front Neurol · In animals
16. Therapeutic potential of neural stem cell-derived exosomes and PRP in Parkinson's disease: A novel regenerative approach.2026 · Tissue Cell · In animals
17. Multiple stimulations of chemoluminescent-expressing mesenchymal-derived dopaminergic transplants safely reinforce limb-use control restoration during swimming in a unilateral Parkinson's disease model.2026 · Behav Brain Res · In animals
18. Olfactory Mucosal Mesenchymal Stem Cell-Derived Exosomal LncA2M-AS1 Ameliorates Parkinson's Disease by Regulating Microglial Glucose Metabolic Reprogramming and Neuroinflammation via the CFL1/ROCK1 Axis.2026 · CNS Neurosci Ther · In animals
19. An injectable nanoreinforced hydrogel for combined GDNF-loaded nanoparticles and mesenchymal stem cell therapy in Parkinson's disease.2026 · Eur J Pharm Sci · In animals
20. Establishment of four induced pluripotent stem cell lines with high polygenic risk score for Parkinson's disease.2026 · Stem Cell Res · In the lab
21. Exploring the potential of resveratrol-enriched cord mesenchymal stem cell derived exosomes in an in vitro Parkinson's model.2026 · Metab Brain Dis · In the lab
22. LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage.2026 · J Neurochem · In the lab
23. iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.2026 · Nat Commun · In the lab
24. Intranasal administration of endometrial mesenchymal stem cells as a suitable approach for Parkinson's disease therapy.2019 · Mol Biol Rep · RetractedRetracted
25. Do adipose tissue-derived mesenchymal stem cells ameliorate Parkinson's disease in rat model?2014 · Hum Exp Toxicol · RetractedRetracted
26. Clearing the way for a transformative stem-cell treatment for Parkinson's disease.2026 · Nature · Other paper
27. Mesenchymal stem cell-derived small extracellular vesicles promote mitochondrial repair of dopaminergic neurons via Homer protein homolog 3 in Parkinson's disease.2026 · Neural Regen Res · Other paper
28. Exosome-Rich Mesenchymal Stem Cell Secretome Improves Symptoms From Parkinson's Disease: A Case Series.2026 · Pain Med Case Rep · Other paper
29. Synergetic pathways for Parkinson's disease therapy: The intersection of exercise and stem cell science.2026 · World J Stem Cells · Other paper

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