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Atrial fibrillation

Current status: Treatable, not yet curable

A heart rhythm problem in which the heartbeat becomes irregular and is sometimes much faster than normal.1 It can cause a fluttering or pounding heartbeat, tiredness, breathlessness and dizziness, but some people notice nothing.2 There is no cure yet, but medicines can control the heartbeat and lower the risk of blood clots and stroke.2 It becomes more common as people get older, especially after 65.1

Read more about Atrial fibrillation
Where research stands todayUpdated 12 Nov 2026

Trial-stage treatments and research studies you can join

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Phase
  1. Trial-stage treatmentPhase 3Taking people
    Tests an etripamil nasal spray for atrial fibrillation with fast heart rate

    Tests etripamil nasal spray against placebo in adults with atrial fibrillation episodes.

    Boise, United StatesAlso Haddon Heights, Jackson, Littleton, Manhattan, Salisbury, Vista, West Hills, YardleyAge 18+
  2. Trial-stage treatmentPhase 3Taking people
    Magnesium Added to Metoprolol for Fast Heart Rate in Atrial Flutter

    Tests magnesium sulfate alongside metoprolol in adults with atrial flutter and a fast heartbeat.

    Oak Lawn, United StatesAge 18+
  3. Trial-stage treatmentPhase 3Taking people
    REGN7508 and REGN9933 for stroke prevention in atrial fibrillation when blood thinners are unsuitable

    Tests REGN7508 and REGN9933 against placebo in adults with atrial fibrillation.

    Amarillo, United StatesAlso Anderson, Atlanta, Bloomfield Hills, Brownsville, Concord, Dallas, Dothan, Farmington Hills, …Age 18+
  4. Trial-stage treatmentTaking people
    Imaging Guidance for Watchman Device Implant in Atrial Fibrillation

    Tests intracardiac echocardiography to guide placement of the Watchman device in adults with atrial fibrillation.

    Cleveland, United StatesAge 18+
  5. Trial-stage treatmentSoon in United States
    Globe Pulsed Field System for Treating Paroxysmal Atrial Fibrillation Symptoms

    Tests the Globe Pulsed Field System in adults with symptomatic paroxysmal atrial fibrillation.

    Bellevue, United StatesAlso JonesboroAge 18+
  6. Trial-stage treatmentPhase 2Taking people
    Tests two experimental clot-blocking drugs against apixaban in atrial fibrillation

    Tests REGN7508 and REGN9933 against apixaban in adults with atrial fibrillation.

    Amarillo, United StatesAlso Atlanta, Boston, Clinton, Covina, Cutler Bay, Dothan, Encinitas, Fairhope, …Age 18+
  7. Trial-stage treatmentPhase 3Taking people
    REGN7508 compared with apixaban to prevent stroke in atrial fibrillation

    Compares REGN7508 with apixaban for preventing stroke in adults with atrial fibrillation.

    Alexander City, United StatesAlso Amarillo, Atlanta, Bloomfield Hills, Boca Raton, Brownsville, Clinton, Concord, Covina, …Age 18+
  8. Trial-stage treatmentTaking people
    Tests a catheter device for treating irregular heartbeat from atrial fibrillation

    Studies long-term safety of the VARIPULSE catheter for paroxysmal atrial fibrillation in adults.

    Aurora, United StatesAlso Austin, Cincinnati, Detroit, Fort Worth, Fountain Valley, Iowa City, Jacksonville, Janesville, …Age 22+
  9. Trial-stage treatmentTaking people
    Comparing two catheters for treating long-lasting atrial fibrillation

    Compares two ablation catheters in adults with persistent atrial fibrillation.

    Atlanta, United StatesAlso Austin, Boston, Fountain Valley, Jacksonville, Jonesboro, Lexington, Miami, Murray, …Age 18 to 80
  10. Trial-stage treatmentTaking people
    VARIPULSE catheter for ablation in persistent atrial fibrillation

    Tests the VARIPULSE catheter in adults with persistent atrial fibrillation having ablation.

    Atlantis, United StatesAlso Aurora, Birmingham, Edgewood, Hartford, Janesville, Jonesboro, Oklahoma City, Philadelphia, …Age 18 to 80
  11. Trial-stage treatmentPhase 2Taking people
    Tests PKN605 pill in people with atrial fibrillation

    Tests the oral drug PKN605 against placebo in adults with atrial fibrillation.

    Camden, United StatesAlso Durham, Murray, New York, Seattle, TupeloAge 18+
  12. Trial-stage treatmentTaking people
    Testing a pulsed field ablation system for atrial fibrillation

    Tests a new heart ablation system in adults with atrial fibrillation.

    Atlanta, United StatesAlso Austin, Boston, Charleston, Columbus, Jonesboro, Mechanicsburg, New York, Tyler, …Age 18+
  13. Trial-stage treatmentPhase 2Taking people
    BAY 3670549 for restoring normal heart rhythm in atrial fibrillation

    Tests BAY 3670549 against placebo in adults with atrial fibrillation.

    Aurora, United StatesAlso Boston, Detroit, Durham, Fort Worth, Maplewood, San Francisco, TylerAge 18 to 85
  14. Trial-stage treatmentTaking people
    Tests a heart catheter procedure for recurring atrial fibrillation after one prior ablation

    Tests a repeat catheter ablation with the Sphere-9 catheter in adults with recurring atrial fibrillation.

    Atlanta, United StatesAlso Birmingham, Boston, Cleveland, Columbus, Dallas, Falls Church, Fort Worth, Kansas City, …Age 18+
  15. Trial-stage treatmentTaking people
    Tests the WATCHMAN Elite device to reduce stroke risk in atrial fibrillation

    Tests the WATCHMAN Elite device in adults with atrial fibrillation who can take blood thinners.

    Charlotte, United StatesAlso JonesboroAge 18+
  16. Trial-stage treatmentTaking people
    Comparing Two Heart Pacing Locations in People With Atrial Fibrillation

    Compares pacing from Bachmann's Bundle versus the right atrial appendage in atrial fibrillation.

    Pittsburgh, United StatesAge 18+
  17. Trial-stage treatmentTaking people
    Kidney Nerve Procedure Added to Heart Ablation for Persistent Atrial Fibrillation

    Tests a kidney nerve procedure added to heart ablation in adults with persistent atrial fibrillation.

    Short Hills, United StatesAge 18+
  18. Trial-stage treatmentTaking people
    Rechecking a Heart Ablation for Atrial Fibrillation During a Later Appendage Closure Procedure

    Checks how well a prior ablation held up in adults with atrial fibrillation.

    Bay Shore, United StatesAge 18+
  19. Trial-stage treatmentTaking people
    Tests a device procedure to prevent new atrial fibrillation after heart surgery

    Tests a device procedure during heart surgery in older adults at risk of atrial fibrillation.

    Ann Arbor, United StatesAlso Atlanta, Austin, Baltimore, Charleston, Chicago, Cincinnati, Clearwater, Cleveland, …Age 65+
  20. Trial-stage treatmentPhase 3Taking people
    Blood-thinning plans after a heart pouch closure device in atrial fibrillation

    Compares lower-dose apixaban with aspirin after Watchman implant in atrial fibrillation.

    Austin, United StatesAge 18+

Where treatment stands

There is no cure for atrial fibrillation yet, but treatment can help manage symptoms and lower the risk of problems like blood clots and stroke.

Where research stands now

On 11 November 2026, 843 trials and studies of atrial fibrillation were open, and 82 treatments were being tested in people. For 45, the highest phase was phase 3, the last large trials before approval; for 22, it was phase 2. From 5 November 2025 to 11 November 2026, articles reported 286 studies of treatments in people, 77 in animals and 6 in the lab. On that date, 14 medicines had a US approval and 7 an EU approval for it. Health pages say there is no cure yet.

We found 26 medicines approved for atrial fibrillation in the EU, the US, Switzerland or France, and 14 being tested in people.

Approved: 26

Officially approved for this disease in the EU, the US, Switzerland or France.

Human testing stage: 14

Being tested in people. Many treatments at this stage are never approved.

Animal testing stage: 4

Worked in animals in a study published in the last 12 months. Most treatments at this stage never reach people.

Words used here

Placebo: a dummy treatment without the medicine, used for comparison.

Phase 1, 2, 3: the steps of testing in people. Phase 1 checks safety, phase 3 is the last step before approval.

Where this comes from

The EU medicines agency (EMA) and its list of medicines in the EU, US prescribing labels (DailyMed, openFDA), the Swiss medicines register (Swissmedic), the French medicines database (ANSM) and the Health Canada drug database, checked on 11 November 2026. Every medicine links to its own official text.

A computer made this list from the official texts: it kept only medicines whose own approval text names the disease, wrote "Who it is for" from that text and checked it against the text a second time. People have not reviewed it yet.

The trials: ClinicalTrials.gov and the EU trials register, as copied into our trial database, checked on 12 November 2026. Every treatment in trials links to its own trial records; the texts are written by AI from them and checked against them by a second AI. People have not reviewed them yet. Placebo, standard medicines used for comparison and procedures are left out.

Phase 3 trials are listed from every country; only some phase 2 trials are listed, so 15 other open phase 2 trials are not listed.

Animal and lab research: studies listed in PubMed and published in the 12 months before 12 November 2026, found by a search for atrial fibrillation. AI chose the treatments from the study summaries and wrote the texts; a second AI checked each one against its study summary. People have not reviewed them yet. Treatments already in the approved or human testing lists are left out. A result in animals or cells does not show that a treatment works in people.

Not medical advice. Talk to your doctor before you change any treatment.

Support organisations

Patient organisations and helplines in United States, for you and your family.

Atrial fibrillation organisations in United States

  • StopAfib.org

    US non-profit founded by an afib patient that provides atrial fibrillation information, patient conferences and awareness campaigns for patients and families.

General support in United States

  • 988 Suicide & Crisis Lifeline

    US national 24/7 free and confidential lifeline for anyone in suicidal crisis or emotional distress, reachable by calling or texting 988 or by chat.

  • MedlinePlus

    Free, easy-to-read health information service of the US National Library of Medicine (NIH) on diseases, conditions, drugs and wellness.

International organisations

Patient organisation umbrella bodies

Offer tissue or data

There are three ways to help research move faster.

Give tissue or bloodA biobank stores your sample so many research teams can use it.No open programme yet
Share your health dataA patient registry collects your health data, without your name, for research.How to join
Take part as a healthy volunteerStudies also need people without the disease, for comparison. Family and friends can help.Volunteer

Treatments approved outside the EU

Medicines for Atrial fibrillation approved in the US or Japan that are not approved in the EU.

Checked on 11 Nov 2026 in the official lists of the US (FDA), Japan (PMDA, approvals since April 2004) and the EU (EMA). 12 uncertain matches are left out.

Check with your insurance

Your health insurer may pay part of the cost, sometimes all of it. This depends on your insurer, your plan and the country, so always ask your insurer before you go. For planned care in the EU, the EEA and Switzerland, ask about form S2.

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About Atrial fibrillation

A heart rhythm problem in which the heartbeat becomes irregular and is sometimes much faster than normal.1 It can cause a fluttering or pounding heartbeat, tiredness, breathlessness and dizziness, but some people notice nothing.2 There is no cure yet, but medicines can control the heartbeat and lower the risk of blood clots and stroke.2 It becomes more common as people get older, especially after 65.1

What is it?

In atrial fibrillation (AF), a problem with the heart's electrical system makes the heartbeat irregular, and sometimes much faster than normal.2,1 The upper and lower parts of the heart stop working together, so the heart may not pump blood as well as it should.1 It is one of the most common heart rhythm problems.1 High blood pressure, narrowed heart arteries, other heart problems, an overactive thyroid, diabetes and sleep apnoea can all lead to it; sometimes the cause is not known.2,1

Anyone can get it, but it is more likely as you get older, especially after 65, and in men.2,1 Obesity, smoking, heavy drinking and some medicines raise the risk.2,1 AF can run in families.1

The first signs

Some people have no symptoms, and AF is found during a routine check-up or when tests are done for something else.2,1

  • an irregular pulse, or a fluttering or pounding heartbeat (palpitations);2
  • a heartbeat faster than 100 beats a minute;2
  • feeling very tired, or less able to exercise;2
  • shortness of breath, dizziness or feeling faint;2
  • chest pain or tightness.2

How doctors find out

If your family doctor thinks you have AF, you are sent to a heart specialist (cardiologist), who checks your heart rate.2 Tests can include a heart trace (ECG), an ultrasound scan of the heart (echocardiogram), a chest X-ray and blood tests.2 You may be asked to wear a heart monitor that records your heart's electrical activity.1 The tests also look for other causes of your symptoms.2

Current treatment

The 2024 ESC guideline (AF-CARE) puts treating other conditions and risk factors first, then avoiding stroke, then easing symptoms with rate or rhythm control, and individualised reassessment over time.Source: ESC

Will it get worse?

AF may happen in brief episodes, or it may be permanent. Symptoms may start and stop on their own, or stop after treatment, or you may always have symptoms.1,2 Without treatment it raises the risk of blood clots, stroke, heart failure and memory problems, which is why treatment aims to lower these risks.1,2 The sooner it is found and treated, the better.1

Medicines: what helps, and what to watch for

Medicines such as beta blockers control the heart rate and rhythm.2 Anticoagulants (often called blood thinners) make blood clots, and so strokes, less likely.3,2 They include warfarin and newer tablets such as apixaban, rivaroxaban, edoxaban and dabigatran.3 Treatment is often lifelong.3

Good to know:

  • the main side effect of anticoagulants is bleeding too easily: watch for blood in your pee or poo, black poo, bad bruising, long nosebleeds, bleeding gums, or coughing or vomiting blood;3
  • for most people, the benefit of an anticoagulant is bigger than the risk of bleeding;3

Exercise and healthy habits help too

  • aim for at least 150 minutes of moderate exercise a week, like walking, bike riding or gardening, but avoid intense exercise and try not to exercise when you have symptoms of atrial fibrillation;2

Procedures and surgery, for some people

Electrical cardioversion uses low-energy shocks to reset your heart rhythm.1,2 In catheter ablation, the heart tissue that sends the faulty signals is scarred on purpose by burning, freezing or high-energy pulses.1,2 Some people have a pacemaker or an implantable defibrillator (ICD) fitted, or heart surgery (the Maze procedure).2,1 For people who cannot take blood thinners, another procedure (left atrial appendage closure) may be an option.1

Is there a cure?

Not yet.2 Treatment helps manage the symptoms and lowers the risk of stroke and other problems.2

See the 842 trials you can join

Sources

Written in plain words by Frontlight from these pages:

  1. MedlinePlus: Atrial Fibrillation
  2. NHS: Atrial fibrillation
  3. NHS: Anticoagulant medicines