Distinguishing chronic myeloid leukemia in megakaryocytic blast crisis from de novo Ph+ acute megakaryoblastic leukemia: a case report and systematic review.

What was studied

This paper reports one person with leukemia and reviews the published studies. The leukemia carried the Philadelphia chromosome. It looked like chronic myeloid leukemia in a blast crisis. That form is hard to tell from a rare acute leukemia. The team sets out to find clues that separate them.

What they found

The person got a tyrosine kinase inhibitor plus chemotherapy. The leukemia went into complete remission. A stem cell transplant was declined because of cost. The person has stayed in deep molecular remission for 35 months so far. The abstract does not give numbers from the review. The abstract does not say how many studies it covered.

What it means for patients

The team says the review shows key features that tell these diseases apart. They say this may help with the diagnosis. They propose a practical plan for diagnosis and treatment.

Why it is not certain yet

This is the course of one person. The remission has been followed for 35 months so far. The abstract does not give the size or quality of the studies reviewed.

Source

Distinguishing chronic myeloid leukemia in megakaryocytic blast crisis from de novo Ph+ acute megakaryoblastic leukemia: a case report and systematic review.

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