Effects of a Chilean Hazelnut-Supplemented Diet on Oxidative Stress and Cytokine Expression in PBMCs of Hypercholesterolemic Adults: A Randomized Controlled Trial.

What was studied

This randomized trial tested a Chilean-style Mediterranean diet with Chilean hazelnuts. It was compared with a low-fat diet. The adults had high cholesterol. The team looked at oxidative stress and inflammation markers in blood immune cells. The diets ran for 6 months. 106 adults were randomized and 81 finished. 47 ate the hazelnut diet and 34 ate the low-fat diet.

What they found

Both diets improved the redox state of the cells. Oxidative damage went down in both groups. Malondialdehyde and carbonyl levels fell. Antioxidant enzyme activities went up. SOD gene activity rose, while CAT gene activity fell despite higher enzyme activity. No significant differences between groups were seen for any marker.

What it means for patients

The authors said both diets gave similar gains in cell redox state. They said better fat quality and more antioxidant-rich food may help cells. They said the role of Chilean hazelnuts needs more study.

Why it is not certain yet

These were secondary outcomes. Not all randomized adults finished. The role of the hazelnut itself is not clear. Only blood immune cells were studied.

Source

Effects of a Chilean Hazelnut-Supplemented Diet on Oxidative Stress and Cytokine Expression in PBMCs of Hypercholesterolemic Adults: A Randomized Controlled Trial.

We restate facts from the source record in our own words. The original wording belongs to its publisher.