The prevalence of frontotemporal dementia: a systematic review and meta-analysis.

What was studied

This was a review and pooled analysis of how common frontotemporal dementia (FTD) is worldwide. FTD is a leading cause of dementia that starts before age 65. No full summary of its global prevalence existed. The team searched many databases for studies up to October 31, 2025. Studies were split by region, age range and diagnostic criteria era. 21 studies were included.

What they found

The pooled global prevalence was 30 cases per 100,000 population. Studies differed hugely from each other. Prevalence was linked to age range. It was not linked to region or to criteria era. A funnel plot looked lopsided, but Egger's test showed no significant small-study effect.

What it means for patients

The authors said the reported prevalence varied widely across studies. They said the overall estimate is relatively low. They said the large variation and study limits call for cautious reading. They said it gives a benchmark for global FTD prevalence. They said more high-quality population-based studies are needed, especially in places like China.

Why it is not certain yet

Heterogeneity was extreme. The authors note study limitations. Some regions are underrepresented, like China. Prevalence figures from different studies are hard to compare.

Source

The prevalence of frontotemporal dementia: a systematic review and meta-analysis.

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