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Sjögren's disease

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Current status: No cure yet

A long-term autoimmune condition in which the immune system attacks the glands that make tears and saliva, so the eyes and mouth become dry.1 Many people also have aching muscles and joints and extreme tiredness.2 There is no cure yet, but eye drops, mouth gels and other medicines ease the symptoms.2 Most people with it are women, and it is most common in adults over 50.1

Read more about Sjögren's disease
Where research stands todayUpdated 13 Nov 2026
Trial-stage treatments you can join–open now
in United StatesStudies published in the last 12 months6418 in people · 46 in animals · 0 in the labSupport organisations3organisations
in United States1 helpline
Offer tissue or dataGive a sample or your health data to research.Treatments outside United StatesWhere it is offered, and who pays.“Miracle cure” fact checkerSaw a cure online? Check it before you pay.

Trial-stage treatments and research studies you can join

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Phase
  1. Trial-stage treatmentPhase 1Taking people
    Tests nivolumab, alone or combined, for advanced cancers in people with autoimmune disorders

    Tests nivolumab, alone or with other treatments, in adults with autoimmune disorders and advanced cancer.

    Atlanta, United StatesAlso Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, …Age 18+
  2. Trial-stage treatmentPhase 3Taking people
    Ianalumab compared with placebo in adults with Sjögren's disease and heavy symptoms

    Tests ianalumab against placebo in adults with Sjögren's disease and high symptom burden.

    Bellaire, United StatesAlso Boston, Charlotte, Clearwater, Cooper City, Corpus Christi, Euless, Houston, Jackson, …Age 18+
  3. Trial-stage treatmentPhase 2Taking people
    Testing DDY391 Against Placebo in Adults With Sjögren's Disease

    Tests DDY391 compared with placebo in adults with Sjögren's disease.

    Allen, United StatesAlso Avondale, Bellaire, Chicago, Clearwater, Corpus Christi, Duncansville, Memphis, Oklahoma City, …Age 18 to 100
  4. Trial-stage treatmentPhase 1Soon in United States
    Tests R-2487 in adults with Sjogren's syndrome

    Tests whether an oral probiotic, R-2487, is safe in adults with Sjogren's syndrome.

    Ann Arbor, United StatesAlso BaltimoreAge 18 to 80
  5. Trial-stage treatmentPhase 2Taking people
    Tests tofacitinib, a pill, in people with Sjogren disease

    Tests the tablet tofacitinib in adults with Sjogren disease, an autoimmune condition.

    Bethesda, United StatesAge 18 to 75
  6. Trial-stage treatmentPhase 3Taking people
    Tests telitacicept against placebo in adults with active primary Sjögren's disease

    Tests telitacicept, compared with placebo, in adults with active Sjögren's disease.

    Allen, United StatesAlso Amarillo, Baytown, Bellaire, Beverly Hills, Boise, Boston, Chandler, Charlotte, …Age 18 to 75
  7. Trial-stage treatmentPhase 1Soon in United States
    BMS-986553 for Adults With Autoimmune Diseases That Have Not Responded to Treatment

    Tests the safety of BMS-986553 in adults with hard-to-treat autoimmune diseases.

    Ann Arbor, United StatesAlso Great Neck, Morristown, Newport Beach, Omaha, Philadelphia, Saint Paul, Salt Lake City, Seattle, …Age 18+
  8. Trial-stage treatmentPhase 1Taking people
    Bone marrow cell injections into salivary glands for dry mouth

    Tests mesenchymal stromal cells in people with dry mouth.

    Madison, United StatesAge 18 to 90
  9. Trial-stage treatmentPhase 1Taking people
    Tests CLN-978 injections for active, moderate to severe Sjogren's disease

    Tests CLN-978, an injected drug, in adults with active Sjogren's disease.

    Brooklyn, United StatesAlso Memphis, Orlando, Plano, Salt Lake City, WebsterAge 18+
  10. Trial-stage treatmentPhase 1Taking people
    Tests ABBV-319 in adults with lupus, Sjogren's disease or rheumatoid arthritis

    Tests the drug ABBV-319 in adults with lupus, Sjogren's or arthritis.

    Avon Park, United StatesAlso Clearwater, Harlingen, Margate, Memphis, Orland Park, TampaAge 18 to 75
  11. Trial-stage treatmentPhase 2Taking people
    Tests AlloNK cell therapy with rituximab in relapsing rheumatic diseases

    Tests AlloNK immune cells with rituximab in adults with relapsing arthritis or myositis.

    Arlington, United StatesAlso Bellaire, Charleston, Charlotte, Chula Vista, Covina, Gainesville, Great Falls, Hixson, …Age 18+
  12. Trial-stage treatmentSoon in United States
    Studying mouth and gut bacteria in Sjögren's disease with a swallowable mini-pill

    Uses a swallowable mini-pill to sample gut and mouth bacteria in adults with Sjögren's disease.

    Boston, United States
  13. Trial-stage treatmentPhase 3Taking people
    Long-term study of dazodalibep in people with Sjögren's syndrome

    Checks long-term safety of dazodalibep in adults with Sjögren's syndrome.

    Avondale, United StatesAlso Baytown, Beckley, Boston, Bothell, Bradenton, Charlotte, Clearwater, Colleyville, …Age 18+
  14. Research studyTaking people
    Collects samples and data from people with leukodystrophy worldwide

    Gathers clinical data and biological samples from people with leukodystrophy for future research.

    Akron, United StatesAlso Atlanta, Baltimore, Boston, Charlottesville, Chicago, Columbus, Houston, Los Angeles, …
  15. Research studyTaking people
    Studying how pain is felt in people with rheumatic diseases

    Measures touch and pain sensitivity in people with rheumatic diseases and healthy volunteers.

    Bethesda, United StatesAge 9 to 85
  16. Research studyTaking people
    Studies how Sjogren's disease begins and affects people over time

    Observes people with Sjogren's disease to learn how it develops and progresses.

    Bethesda, United StatesAge 16 to 100
  17. Research studyTaking people
    Studying Diseases That Affect the Salivary Glands

    Collects samples and data from people with salivary gland disease and their relatives.

    Bethesda, United StatesAge 4 to 100
  18. Research study
    Compares immune cells in people with lupus, infections, and healthy people

    Compares B lymphocytes from people with autoimmune disease, infections, and healthy people.

    Atlanta, United StatesAge 18+
  19. Trial-stage treatmentTaking people
    Online Health Course Tested for People With Rheumatic Conditions and Mood Disorders

    Tests an online diet and self-care course in adults with arthritis, lupus, or anxiety.

    Iowa City, United StatesAge 18 to 100
  20. Research studySoon in United States
    Follow-up study of people with dry eye and Sjögren's syndrome

    Follows people from an earlier study who have dry eye, with or without Sjögren's syndrome.

    Philadelphia, United StatesAge 18+

Where treatment stands

There is no cure for Sjögren's disease yet, but treatments can help ease the symptoms and prevent problems it can cause.

Where research stands now

On 11 November 2026, 92 trials and studies of Sjögren's disease were open. Of 61 treatments being tested in people, by highest phase, 6 were in phase 3 (the last stage before approval), 20 in phase 2, 7 in phase 1/2, 21 in phase 1 and 7 in early phase 1. From 5 November 2025 to 11 November 2026, articles reported 18 treatment studies in people, 46 in animals and 0 in the lab. On 11 November 2026, 3 medicines had a US approval naming this disease, and 0 had an EU approval. Health pages say there is currently no cure.

We found 4 medicines approved for Sjögren's disease in the EU, the US, Switzerland or France, and 6 being tested in people.

Approved: 4

Officially approved for this disease in the EU, the US, Switzerland or France.

Human testing stage: 6

Being tested in people. Many treatments at this stage are never approved.

Animal testing stage: 4

Worked in animals in a study published in the last 12 months. Most treatments at this stage never reach people.

Words used here

Placebo: a dummy treatment without the medicine, used for comparison.

Phase 1, 2, 3: the steps of testing in people. Phase 1 checks safety, phase 3 is the last step before approval.

Where this comes from

The EU medicines agency (EMA) and its list of medicines in the EU, US prescribing labels (DailyMed, openFDA), the Swiss medicines register (Swissmedic), the French medicines database (ANSM) and the Health Canada drug database, checked on 11 November 2026. Every medicine links to its own official text.

A computer made this list from the official texts: it kept only medicines whose own approval text names the disease, wrote "Who it is for" from that text and checked it against the text a second time. People have not reviewed it yet.

The trials: ClinicalTrials.gov and the EU trials register, as copied into our trial database, checked on 12 November 2026. Every treatment in trials links to its own trial records; the texts are written by AI from them and checked against them by a second AI. People have not reviewed them yet. Placebo, standard medicines used for comparison and procedures are left out.

Phase 3 trials are listed from every country; only some phase 2 trials are listed, so 13 other open phase 2 trials are not listed.

Animal and lab research: studies listed in PubMed and published in the 12 months before 12 November 2026, found by a search for Sjögren's disease. AI chose the treatments from the study summaries and wrote the texts; a second AI checked each one against its study summary. People have not reviewed them yet. Treatments already in the approved or human testing lists are left out. A result in animals or cells does not show that a treatment works in people.

Not medical advice. Talk to your doctor before you change any treatment.

Support organisations

Patient organisations and helplines in United States, for you and your family.

Sjögren's disease organisations in United States

  • Sjögren's Foundation

    US nonprofit for people with Sjögren's disease: updates on research, treatments, events, advocacy and patient resources.

    sjogrens.org

General support in United States

  • 988 Suicide & Crisis Lifeline

    US national 24/7 free and confidential lifeline for anyone in suicidal crisis or emotional distress, reachable by calling or texting 988 or by chat.

    988lifeline.org
  • MedlinePlus

    Free, easy-to-read health information service of the US National Library of Medicine (NIH) on diseases, conditions, drugs and wellness.

    medlineplus.gov

International organisations

Patient organisation umbrella bodies

Offer tissue or data

There are three ways to help research move faster.

Give tissue or bloodA biobank stores your sample so many research teams can use it.No open programme yet
Share your health dataA patient registry collects your health data, without your name, for research.How to join
Take part as a healthy volunteerStudies also need people without the disease, for comparison. Family and friends can help.Volunteer

Treatments approved outside the EU

Medicines for Sjögren's disease approved in the US or Japan that are not approved in the EU.

Checked on 11 Nov 2026 in the official lists of the US (FDA), Japan (PMDA, approvals since April 2004) and the EU (EMA). 2 uncertain matches are left out.

Check with your insurance

Your health insurer may pay part of the cost, sometimes all of it. This depends on your insurer, your plan and the country, so always ask your insurer before you go. For planned care in the EU, the EEA and Switzerland, ask about form S2.

“Miracle cure” fact checker

Social media spreads misinformation. Paste what you read here, and we'll tell you whether there is scientific evidence behind it.

What you paste is checked with AI (Anthropic, USA) and is not stored. Please leave out names and other personal details.

Before you pay for anything, ask three things

  1. Is there a published study in people?
  2. Can I have the full price in writing?
  3. What does my doctor say?

“Cures” others already fact-checked

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About Sjögren's disease

A long-term autoimmune condition in which the immune system attacks the glands that make tears and saliva, so the eyes and mouth become dry.1 Many people also have aching muscles and joints and extreme tiredness.2 There is no cure yet, but eye drops, mouth gels and other medicines ease the symptoms.2 Most people with it are women, and it is most common in adults over 50.1

What is it?

Sjögren's disease, also called Sjögren's syndrome, is a long-term autoimmune condition.1,2 The immune system attacks the glands that make fluids such as tears and saliva (spit), so they stop working properly.2 Why this happens is not clear; genes, hormones and an earlier viral or bacterial infection may play a part.2 Some people have it on its own; others also have a condition such as rheumatoid arthritis or lupus.1

Most people with it are women.1,2 It can start at any age, but it is most common in adults over 50, and it affects people of every background.1

The first signs

The signs can be mild or severe.2,1

  • dry eyes;2,1
  • a dry mouth;2,1
  • aching muscles and joints;2,1
  • extreme tiredness that does not go away.2,1

Other signs can be dry or itchy skin, a cough that does not go away, a hoarse voice, acid reflux, swollen glands in the cheeks, neck or under the jaw, and vaginal dryness.2 A very dry mouth can lead to tooth decay, gum disease and trouble swallowing.2

How doctors find out

There is no single test, and other conditions can cause the same signs, so your family doctor first checks for more common causes and may send you to a specialist.2,1 Tests can include blood tests, eye tests, and a saliva test where you spit into a pot for 5 minutes.2 An X-ray of the saliva glands can show if they are blocked, and a small piece of skin that contains saliva glands may be taken from your lip and looked at under a microscope (a lip biopsy). Sometimes you may also have an ultrasound scan.2

Current treatment

Treatment depends on the symptoms: medicines keep the eyes and mouth moist or boost tears and saliva, painkillers ease aches, and immune-calming medicines are used for severe disease.Source: NHS

Will it get worse?

It affects people differently, and the symptoms can flare up and then settle.2 Doing too much and not resting enough may set off a flare-up.2 If your symptoms are severe, they can affect your daily life. For example, a dry mouth can make eating difficult, and dry eyes may cause vision problems. You may also have muscle and joint pain and feel tired all the time.2 Most people live into old age, with a normal life expectancy.2 The risk of a cancer of the lymph glands (non-Hodgkin lymphoma) is higher, but it is still rare.2,1

Medicines: what helps, and what to watch for

Treatment depends on your symptoms.2,1 Your doctor may prescribe medicines that keep the eyes and mouth moist or help the glands make more tears and saliva, medicines for muscle and joint pain, and, for severe disease, medicines that calm the immune attack on the glands.2,1 For severe joint pain, a short course of steroid tablets may be used.2 Small plugs in the tear ducts can keep tears in the eyes.1

Good to know:

  • a pharmacist can sell you eye drops, skin cream, mouth gel and mouthwash;2
  • paracetamol can help muscle and joint pain; your doctor can prescribe something stronger if needed;2

Is there a cure?

There is currently no cure for Sjögren's.2

See the 92 trials you can join

Sources

Written in plain words by Frontlight from these pages:

  1. MedlinePlus: Sjögren's Disease
  2. NHS: Sjögren's syndrome