Bipolar disorder: trials for referral
259 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
Type a city to sort by distance. The distance is worked out in your browser; the city is not sent anywhere.
259 trials shown
No phase1 site
RecruitingDenmark
NCT07920302
Affective Cognitive Training in Mood Disorders and High-risk Relatives
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Registry updated 5 Nov 2026
Registry record: ClinicalTrials.govPhase 287 sites
RecruitingArgentina, Brazil, China, India, Japan, Mexico
NCT07286175
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Eli Lilly and Company
Registry updated 4 Nov 2026
Registry record: ClinicalTrials.govPhase 3106 sites
RecruitingArgentina, Bulgaria, China, Denmark, France, Israel
NCT07140913
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Bristol-Myers Squibb
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase7 sites
RecruitingFrance
NCT06507787
Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects
Alcediag
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 365 sites
RecruitingColombia, Serbia, United States
NCT06229210
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Intra-Cellular Therapies, Inc.
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06462196
Natural History of Depression, Bipolar Disorder and Suicide Risk
National Institute of Mental Health (NIMH)
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 368 sites
RecruitingColombia, India, Serbia, United States
NCT06372964
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Intra-Cellular Therapies, Inc.
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 21 site
Not yet recruitingUnited States
NCT07913542
N-Acetylcysteine for Bipolar and Alcohol Use Disorders
Medical University of South Carolina
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingPoland
NCT07437833
Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar Disorder
Poznan University of Physical Education
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT07910318
Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders
Assiut University
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 43 sites
RecruitingDenmark
NCT05913947
Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)
Aalborg University Hospital
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT07905378
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
Korea University Anam Hospital
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingChina
NCT07903246
A Prospective Study of Anxiety, Depression, and Bipolar Disorder in People
Second Affiliated Hospital, Zhejiang University, School of Medicine
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingChina
NCT07246044
HD-tDCS for Adolescent Bipolar Depression Targeting S1
Jiangsu Province Nanjing Brain Hospital
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
By invitation onlySouth Korea
NCT07880015
Digital Phenotypes for Predicting Depression_Validation
Korea University Anam Hospital
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 3173 sites
RecruitingArgentina, Australia, Bulgaria, China, Denmark, Spain
NCT06929273
A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)
Bristol-Myers Squibb
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govNo phase6 sites
By invitation onlyUnited States
NCT07130500
Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization
Stanford University
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govPhase 374 sites
RecruitingArgentina, Australia, Bulgaria, Hungary, Japan, New Zealand
NCT06951698
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
Bristol-Myers Squibb
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingTaiwan
NCT05977023
NMDA Receptor Modulation for the Treatment of Bipolar I Disorder
China Medical University Hospital
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govPhase 31 site
RecruitingSweden
NCT07664852
Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression
Daniel Lindqvist
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingCanada
NCT07890805
Evaluating the PolarUs App in People With Bipolar Disorder
University of British Columbia
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govPhase 378 sites
RecruitingChina, Spain, Croatia, Israel, India, Italy
NCT06951711
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)
Bristol-Myers Squibb
Registry updated 20 Oct 2026
Registry record: ClinicalTrials.govNo phase16 sites
RecruitingFrance
NCT07881016
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
Fondation FondaMental
Registry updated 19 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruiting
NCT07879118
Effect of Occupational Therapy on Psychosocial Parameters and Functioning in Individuals With Severe Mental Illness
Biruni University
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingBahrain
NCT07879131
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness
Alexandria University
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Recruiting
NCT07858565
Quality of Life, Safety and Compliance of Patients Using Monotherapy or Combinatorial Therapy With Quetiapine for Treatment of Schizophrenia or Bipolar Affective Disorder
Bosnalijek D.D
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govNo phase3 sites
Not yet recruitingFrance
NCT07872878
BAROMETRE : Study on the Prognosis and Course of Individuals With Bipolar Spectrum Disorder
University Hospital, Angers
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govPhase 268 sites
RecruitingUnited Kingdom, United States
NCT06656416
ALTO-100 in Bipolar Disorder With Depression (BD-D)
Alto Neuroscience
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT03829787
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
University Hospitals Cleveland Medical Center
Registry updated 9 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingDenmark
NCT07404085
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States94 open trials
- France33 open trials
- China25 open trials
- Canada21 open trials
- Denmark13 open trials
- United Kingdom10 open trials
- Italy9 open trials
- Poland8 open trials
- Spain8 open trials
- Brazil7 open trials
- Argentina6 open trials
- India6 open trials
- Norway6 open trials
- Romania5 open trials
- Sweden5 open trials
- Germany5 open trials
- Netherlands5 open trials
- Japan4 open trials
- Israel4 open trials
- Ukraine4 open trials
- Colombia4 open trials
- Mexico3 open trials
- Bulgaria3 open trials
- Serbia3 open trials
- South Korea3 open trials
- Austria3 open trials
- Puerto Rico2 open trials
- Slovakia2 open trials
- Hungary2 open trials
- Australia2 open trials
- Croatia2 open trials
- Taiwan2 open trials
- New Zealand1 open trials
- Bahrain1 open trials
- Monaco1 open trials
- Russia1 open trials
- Hong Kong SAR China1 open trials
- Belgium1 open trials
- Greece1 open trials
- Iceland1 open trials
- Switzerland1 open trials
- Chile1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Centro de Investigación Biomédica en Red de Salud Mental
Madrid, Spain
0 trials · 223 publications · ROR
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
0 trials · 41 publications · ROR
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Barcelona, Spain
0 trials · 169 publications · ROR
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
Hempstead, United States
0 trials · 68 publications · ROR
Florey Institute of Neuroscience and Mental Health
Melbourne, Australia
0 trials · 58 publications · ROR
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
4 trials · 40 publications · ROR
National Institute of Mental Health and Neurosciences
Bengaluru, India
0 trials · 53 publications · ROR
Rutgers, The State University of New Jersey
New Brunswick, United States
0 trials · 48 publications · ROR
South London and Maudsley NHS Foundation Trust
London, United Kingdom
2 trials · 89 publications · ROR
The University of Texas Health Science Center at Houston
Houston, United States
7 trials · 97 publications · ROR
The University of Texas Southwestern Medical Center
Dallas, United States
0 trials · 42 publications · ROR
University Hospitals Cleveland Medical Center
Cleveland, United States
1 trials · 44 publications · ROR
University of North Carolina at Chapel Hill
Chapel Hill, United States
1 trials · 78 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
New in the registry
Affective Cognitive Training in Mood Disorders and High-risk Relatives
NCT07920302 · No phase · Denmark
Source: ClinicalTrials.govClosed for recruitment
An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)
NCT07217860 · Phase 3 · Bulgaria, Germany, Spain, France, United States
Source: ClinicalTrials.govOpened for recruitment
NCT05973786 · Phase 3 · Austria, Germany, Spain, United Kingdom, Greece, Italy
Source: ClinicalTrials.govStatus changed: Completed → Running, not recruiting
NCT05044611 · Phase 4 · France
Source: ClinicalTrials.govStatus changed: Running, not recruiting → Completed
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
NCT03748446 · Early Phase 1 · Germany, Spain, Finland, Poland, Romania, Slovakia
Source: ClinicalTrials.govPhase changed: Phase 3 → Early Phase 1
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
NCT03748446 · Early Phase 1 · Germany, Spain, Finland, Poland, Romania, Slovakia
Source: ClinicalTrials.govClosed for recruitment
NCT05973786 · Phase 3 · Austria, Germany, Spain, United Kingdom, Greece, Italy
Source: ClinicalTrials.govOpened for recruitment
An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)
NCT07217860 · Phase 3 · Bulgaria, Germany, Spain, France, United States
Source: ClinicalTrials.govPhase changed: No phase → Phase 4
NCT05656469 · Phase 4 · Germany, Spain, United Kingdom, Netherlands, Romania, Serbia
Source: ClinicalTrials.gov
New reviews, guidelines and randomised trials in PubMed
Systematic review
Neuroimaging Studies of Bipolar Disorder With Suicide Attempts: A Systematic Review.
Alpha psychiatry · PubMed
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
Phase 2Ended 24 Sept 2026
Completed253 participants
NCT07046494
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder
No phaseEnded 15 Aug 2026
Completed24 participants
NCT02242110
Brief Treatment for Trauma Nightmares in Trauma-exposed Adults With Bipolar Disorder
Phase 1Ended 3 Aug 2026
Completed107 participants
NCT06993662
The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective.
Phase 2Ended 31 Jul 2026
Completed51 participants
NCT05064319
Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
No phaseEnded 25 Jul 2026
Completed75 participants
NCT06365021
ACT for Syndromic and Subsyndromic Depression in Bipolar Disorder
No phaseEnded 30 Jun 2026
Completed97 participants
NCT06672562
Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
Phase 2/3Ended 30 Jun 2026
Completed100 participants
NCT05054699
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
No phaseEnded 30 Jun 2026
Completed43 participants
NCT07733297
The Effect of Cognitive Behavioral Psychoeducation on Internalized Stigma in Individuals With Bipolar Disorder
Phase 3Ended 24 Jun 2026
Stopped early1 participants
NCT05603104
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
Reason given: The site in Israel stopped recruitment due to logistic reasons. Other sites are recruiting for 2023-506602-39-00, 2023-506605-19-00, 2023-506617-21-00.
No phaseEnded 15 Jun 2026
No phaseEnded 11 Jun 2026
No phaseEnded 11 Jun 2026
No phaseEnded 31 May 2026
Completed53 participants
NCT07043803
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
No phaseEnded 29 May 2026
Completed176 participants
NCT04675593
Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders
Phase 2Ended 26 May 2026
Completed7 participants
NCT02481245
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
Phase 3Ended 20 May 2026
Completed351 participants
NCT06462612
Study of Lumateperone in the Treatment of Patients With Bipolar Mania
Phase 4Ended 16 May 2026
No phaseEnded 15 May 2026
No phaseEnded 27 Apr 2026
Phase 3Ended 17 Apr 2026
Completed60 participants
2024-513037-20-00
A study to assess the efficacy and safety of lumateperone in patients with Bipolar Mania
No phaseEnded 17 Apr 2026
Completed28 participants
NCT06426134
Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS
Phase 3Ended 5 Mar 2026
Completed354 participants
NCT06462586
Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania
No phaseEnded 1 Mar 2026
Completed56 participants
NCT04284267
Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders
No phaseEnded 28 Feb 2026
Completed34 participants
NCT06954350
Pain, Sleep Quality, Eating Habits and Physical Activity Level in Patients With Bipolar Disorder
No phaseEnded 13 Feb 2026
Completed50 participants
NCT06721858
Effects of Emotion-focused Therapy (EFT) on Mood Awareness and Emotional Reactivity in Bipolar Patients Awareness and Emotional Reactivity
Phase 2Ended 28 Jan 2026
Completed41 participants
NCT05339074
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression
No phaseEnded 23 Jan 2026
Completed120 participants
NCT06256367
Observational Study of Oral Cariprazine Capsules to Assess Change in Disease Activity in Adult Participants With Bipolar I Disorder
No phaseEnded 23 Jan 2026
Completed65 participants
NCT05380583
Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study
Phase 3Ended 22 Jan 2026
Completed80 participants
2024-513036-26-00
A study to assess the efficacy and safety of lumateperone in patients with Bipolar Mania
No phaseEnded 19 Jan 2026
Completed64 participants
NCT07643714
Effects of ACT-Based Psychoeducation on Caregivers of Individuals With Mental Disorders
No phaseEnded 2 Jan 2026
No phaseEnded 31 Dec 2025
Completed132 participants
NCT04358900
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
No phaseEnded 31 Dec 2025
Completed155 participants
NCT07834112
Body Weight Changes After Switching to Lurasidone for Antipsychotic-induced Weight Gain in Bipolar Disorder
No phaseEnded 30 Dec 2025
Completed343 participants
NCT05030272
Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
No phaseEnded 30 Dec 2025
Completed60 participants
NCT07548359
Psychiatric Nursing Intervention for Caregivers of Patients With Bipolar Disorder
No phaseEnded 20 Dec 2025
Completed186 participants
NCT04298450
ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention
Phase 2Ended 10 Dec 2025
Completed161 participants
NCT06605599
Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipolar I or II Disorder
No phaseEnded 1 Dec 2025
Completed70 participants
NCT07404943
The Effect of Telenursing on Functionality and Treatment Adherence in Bipolar Disorder
- The effect of tele-nursing counseling on functioning and medication adherence in individuals with bipolar disorder: A randomized controlled trial. · Archives of psychiatric nursing, 2026
No phaseEnded 26 Nov 2025
Phase 2Ended 21 Nov 2025
Phase 2Ended 14 Nov 2025
No phaseEnded 14 Nov 2025
Completed191 participants
NCT05725785
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness
Early Phase 1Ended 6 Nov 2025
Completed13 participants
NCT03748446
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
No phaseEnded 31 Oct 2025
Completed3100 participants
NCT07129408
Epidemiological Study on the Prevalence of Mental Disorders in Slovakia
Phase 2Ended 31 Oct 2025
Completed20 participants
NCT06620042
FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
No phaseEnded 27 Oct 2025
Completed31 participants
NCT00590265
Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression
No phaseEnded 24 Oct 2025
Completed146 participants
NCT04696471
Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults With Bipolar Disorder
Phase 2Ended 7 Oct 2025
Completed33 participants
NCT07116694
Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder
Phase 3Ended 6 Oct 2025
No phaseEnded 2 Oct 2025
No phaseEnded 30 Sept 2025
Completed138 participants
NCT04127604
Post-Hospital Intervention for Veterans With Comorbid Bipolar and Substance Use Disorders
Phase 1Ended 12 Sept 2025
Completed43 participants
NCT07549581
A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode
No phaseEnded 3 Sept 2025
Completed15 participants
NCT06335875
Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones
No phaseEnded 1 Sept 2025
Completed120 participants
NCT07857213
Seasonality, Chronotype, Impulsivity, and Suicidality in Mood Disorder Patients
No phaseEnded 1 Sept 2025
Completed82 participants
NCT06782763
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
No phaseEnded 31 Aug 2025
No phaseEnded 31 Aug 2025
Completed71 participants
NCT05268809
Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?
No phaseEnded 29 Aug 2025
Completed47 participants
NCT04118283
Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness
Phase 3Ended 15 Aug 2025
Completed452 participants
NCT05658510
Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III)
No phaseEnded 12 Aug 2025
Completed62 participants
NCT07140042
Physical Fitness, Physical Activity Level, Depression and Quality of Life in Bipolar and Schizophrenia Patients
Not medical advice. fetched 6 Nov 2026