Systemic sclerosis (scleroderma): trials for referral
245 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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245 trials shown
Phase 1/22 sites
RecruitingUnited States
NCT06434363
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
M.D. Anderson Cancer Center
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 1/223 sites
RecruitingAustralia, Germany, Spain, United Kingdom, Sweden, United States
NCT07295847
A Study of AZD0120 in Autoimmune Diseases
AstraZeneca
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 118 sites
RecruitingCanada, United States
NCT07085104
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Allogene Therapeutics
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 1/212 sites
RecruitingUnited States
NCT06733935
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Nkarta, Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 10 sites
Not yet recruiting
NCT07906145
A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases
Shanghai Qilu Pharmaceutical Research and Development Center LTD
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT07650565
Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs)
University Hospital, Montpellier
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT01793168
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Sanford Health
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 122 sites
RecruitingChina
NCT07732309
A Study of ATG-201 in Adult Participants With Autoimmune Diseases
Antengene Biologics Limited
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 3133 sites
RecruitingArgentina, Austria, Australia, Belgium, Bulgaria, Brazil
NCT07691970
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
AstraZeneca
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 117 sites
RecruitingGermany, Spain, United States
NCT06925542
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govPhase 351 sites
Not yet recruitingAustria, Belgium, Bulgaria, Czechia, Germany, Spain
2026-526419-13-00
Rollover Study for Participants Who Have Completed a Previous Clinical Study with Anifrolumab (Saphnelo) and Clinically Benefited from Continued Treatment.
AstraZeneca AB
Registry updated 26 Oct 2026
Registry record: EU CTISNo phase1 site
RecruitingUnited States
NCT01776398
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Weill Medical College of Cornell University
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingChina
NCT06379646
An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease
China Immunotech (Beijing) Biotechnology Co., Ltd.
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingFrance
NCT07888842
A Clinical Study on Systemic Sclerosis and the Validation of French-language Questionnaires Assessing Disability, Quality of Life, and Disease Status.
Assistance Publique - Hôpitaux de Paris
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingAustralia
NCT07778446
A Study to Test CRT-402 in Refractory Autoimmune Disease
Myeloid Therapeutics
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingChina
NCT06978647
A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases
China Immunotech (Beijing) Biotechnology Co., Ltd.
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingChina
NCT07104721
A Clinical Study of YTS109 Cell for R/R Autoimmune Diseases
China Immunotech (Beijing) Biotechnology Co., Ltd.
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govPhase 27 sites
RecruitingFrance
2023-508432-53-00
SUBCUTANEOUS INJECTIONS OF AUTOLOGOUS CULTURED ADIPOSE-DERIVED STROMA/ STEM CELLS TO HEAL REFRACTORY ISCHEMIC DIGITAL ULCERS IN PATIENTS WITH SCLERODERMA
Centre Hospitalier Universitaire De Toulouse
Registry updated 20 Oct 2026
Registry record: EU CTISPhase 21 site
Not yet recruitingCanada
NCT07734012
Mycophenolate After Stem Cell Transplant for Systemic Sclerosis
Ottawa Hospital Research Institute
Registry updated 19 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingChina
NCT07413341
A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases
Therorna
Registry updated 19 Oct 2026
Registry record: ClinicalTrials.govPhase 1/210 sites
RecruitingGermany, Spain, United Kingdom
NCT07473154
Controlling Hyperactive Immunity With Long-lived Lymphocytes
Quell Therapeutics Limited
Registry updated 19 Oct 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
Not yet recruitingUnited States
NCT07697274
Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial
Medical University of South Carolina
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govPhase 2/310 sites
RecruitingUnited States
NCT06328777
RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis
Cabaletta Bio
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govPhase 1/24 sites
RecruitingGermany, Spain
2025-523971-46-00
Study QEL-005-CLN-01. Phase I/II study of QEL-005 in patients with diffuse cutaneous systemic sclerosis (dcSSc) and in patients with difficult to treat rheumatoid arthritis (D2TRA).
Quell Therapeutics Limited
Registry updated 15 Oct 2026
Registry record: EU CTISPhase 226 sites
RecruitingSpain, France, Italy, Netherlands, Poland, Romania
2025-523288-39-00
Evaluation of MTX-474 in Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Mediar Therapeutics Inc.
Registry updated 14 Oct 2026
Registry record: EU CTISPhase 3248 sites
RecruitingArgentina, Austria, Australia, Belgium, Bulgaria, Brazil
NCT07497087
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis
Boehringer Ingelheim
Pre-treatment window Registry sentence: “Patients may be either untreated or on stable treatment with permitted immunosuppressive/immunomodulatory agents and/or nintedanib.”
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruiting
NCT07858838
Using AI-Assisted Cameras to Track Hand Exercises in Scleroderma Patients
Istanbul University - Cerrahpasa
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govPhase 123 sites
Not yet recruitingBelgium, Germany, France, Netherlands, Poland, United States
NCT07873931
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Bristol-Myers Squibb
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govPhase 24 sites
RecruitingFrance
NCT07493395
Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy
University Hospital, Montpellier
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingAustralia
NCT07649265
A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body
Otsuka Pharmaceutical Development & Commercialization, Inc.
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- China64 open trials
- France56 open trials
- United States51 open trials
- Germany25 open trials
- Spain21 open trials
- Italy14 open trials
- Netherlands13 open trials
- United Kingdom12 open trials
- Australia12 open trials
- Canada11 open trials
- Poland11 open trials
- Romania8 open trials
- Belgium8 open trials
- Israel8 open trials
- Sweden7 open trials
- Brazil6 open trials
- Greece6 open trials
- Portugal5 open trials
- Japan5 open trials
- Austria5 open trials
- Bulgaria5 open trials
- South Korea5 open trials
- Denmark5 open trials
- Mexico4 open trials
- Argentina4 open trials
- Thailand3 open trials
- Czechia3 open trials
- Finland3 open trials
- Switzerland3 open trials
- Norway3 open trials
- Egypt3 open trials
- India2 open trials
- Taiwan2 open trials
- Croatia2 open trials
- Slovakia1 open trials
- Philippines1 open trials
- South Africa1 open trials
- Chile1 open trials
- Vietnam1 open trials
- Malaysia1 open trials
- Lithuania1 open trials
- Estonia1 open trials
- Hungary1 open trials
- Georgia1 open trials
- Singapore1 open trials
- Colombia1 open trials
- New Zealand1 open trials
- Serbia1 open trials
- Slovenia1 open trials
- Bangladesh1 open trials
- Pakistan1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Brescia, Italy
5 trials · 68 publications · ROR
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
0 trials · 55 publications · ROR
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
4 trials · 49 publications · ROR
Fraunhofer Institute for Translational Medicine and Pharmacology
Frankfurt am Main, Germany
0 trials · 29 publications · ROR
Institut de Recherche en Santé, Environnement et Travail
Rennes, France
0 trials · 33 publications · ROR
Instituto de Parasitología y Biomedicina "López - Neyra"
Armilla, Spain
0 trials · 22 publications · ROR
Manchester University NHS Foundation Trust
Manchester, United Kingdom
3 trials · 48 publications · ROR
NIHR Manchester Biomedical Research Centre
Manchester, United Kingdom
0 trials · 53 publications · ROR
Research Institute of the McGill University Health Centre
Montreal, Canada
0 trials · 25 publications · ROR
The University of Texas Health Science Center at Houston
Houston, United States
5 trials · 112 publications · ROR
University Medical Center of the Johannes Gutenberg University Mainz
Mainz, Germany
0 trials · 27 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Phase changed: No phase → Phase 2/3
A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
NCT07403188 · Phase 2/3 · Germany, United States
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 6 Oct 2026
No phaseEnded 10 Sept 2026
Completed238 participants
NCT06587828
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
No phaseEnded 3 Sept 2026
No phaseEnded 3 Aug 2026
Completed24 participants
NCT07661836
Personalized Online Occupational Therapy Intervention for Adults With Scleroderma
No phaseEnded 13 Jul 2026
Completed586 participants
NCT04325217
Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated Interstitial Lung Disease (SSc-ILD) in Japan
No phaseEnded 21 Apr 2026
Completed15 participants
NCT05533034
Personalized Home Respiratory Rehabilitation Program for Subjects With Systemic Sclerosis With Early Lung Disease
Phase 3Ended 23 Mar 2026
Phase 4Ended 19 Mar 2026
Completed60 participants
NCT04464434
Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis
No phaseEnded 1 Mar 2026
No phaseEnded 1 Mar 2026
Completed460 participants
NCT07277491
Assessment of Nutritional Status in Rheumatic Diseases and Association to Disease Activity
Phase 2Ended 30 Jan 2026
Phase 3Ended 8 Jan 2026
Completed151 participants
2024-516050-22-00
TRIAL EVALUATING EFFICACY AND SAFETY OF HYDROXYCHLOROQUINE VERSUS PLACEBO IN EARLY SYSTEMIC SCLEROSIS (SSc)
No phaseEnded 2 Jan 2026
Completed511 participants
NCT06373263
Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1
No phaseEnded 31 Dec 2025
No phaseEnded 30 Dec 2025
Completed46 participants
NCT07469865
Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST)
Phase 2Ended 18 Dec 2025
No phaseEnded 17 Dec 2025
No phaseEnded 11 Dec 2025
Completed56 participants
NCT03271333
Description of the Functional Evolution of Diffuse Infiltrating Pneumonia Associated With Systemic Scleroderma.
No phaseEnded 1 Dec 2025
No phaseEnded 5 Nov 2025
No phaseEnded 31 Oct 2025
No phaseEnded 2 Sept 2025
Completed50 participants
NCT04223817
7.0 Tesla Resonance Magnetic Imaging of the Hand in Systemic Sclerosis
Phase 4Ended 30 Aug 2025
Completed34 participants
NCT07472166
Efficacy of Tofacitinib on Skin Thickening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With Methotrexate
Phase 1/2Ended 11 Aug 2025
No phaseEnded 1 Aug 2025
Completed20 participants
NCT06999226
RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach
No phaseEnded 28 Jul 2025
Completed43 participants
NCT07402863
Self-Guided Resilience-Building Energy Management to Enhance Well-being (RENEW) Intervention for People With Systemic Sclerosis (SSc)
Phase 2Ended 23 Jul 2025
Phase 1Ended 14 Jul 2025
Phase 1Ended 11 Jul 2025
Completed56 participants
NCT05462522
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of RO7303509 in Participants With Systemic Sclerosis
No phaseEnded 30 Jun 2025
No phaseEnded 31 May 2025
Completed12 participants
NCT07212959
As Part of a Pilot Study, Visualization of Inflammatory Activity in Systemic Sclerosis Using CXCR4 PET/CT
No phaseEnded 1 May 2025
Completed169 participants
NCT04246528
SPIN Self-Management Feasibility Trial With Progression to Full-scale Trial (SPIN-SELF)
No phaseEnded 30 Apr 2025
No phaseEnded 17 Apr 2025
Completed851 participants
NCT06772896
Evaluating the Effect of Questionnaire Context on the Reporting of Somatic Items Among People With Systemic Sclerosis
Phase 3Ended 11 Apr 2025
Phase 1Ended 31 Mar 2025
No phaseEnded 30 Mar 2025
Completed30 participants
NCT07012655
Color Doppler Ultrasonography Evaluation of Abdominal and Peripheral Vasculopathy in Systemic Sclerosis Patients
No phaseEnded 11 Feb 2025
No phaseEnded 22 Jan 2025
No phaseEnded 31 Dec 2024
Completed112 participants
NCT06291142
Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot
No phaseEnded 31 Dec 2024
Completed9 participants
NCT04875078
UVA-1 for Treatment of Skin Tightening and Improvement of Hand Function in Scleroderma
Phase 3Ended 31 Dec 2024
Completed30 participants
NCT05416697
Effectiveness of Cannabinoids on Appetite in Scleroderma
- Efficacy of cannabis oil on appetite and quality of life in systemic sclerosis patients: a randomized placebo-controlled trial. · Journal of cannabis research, 2025
No phaseEnded 31 Dec 2024
Phase 2Ended 19 Dec 2024
Completed84 participants
2023-509782-20-00
A Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis
Phase 2Ended 18 Dec 2024
Completed167 participants
NCT04781543
A Open-label Study to Evaluate the Efficacy, Safety, Tolerability of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis
Phase 3Ended 15 Nov 2024
Completed60 participants
NCT06758947
Use of Selective JAK Inhibitor in ILD and Skin Tightness of Systemic Sclerosis Versus MMF
No phaseEnded 30 Oct 2024
No phaseEnded 4 Oct 2024
Early Phase 1Ended 24 Sept 2024
Phase 2Ended 11 Sept 2024
Phase 2Ended 30 Jul 2024
Completed6 participants
NCT05214794
An Open-label, Phase 2 Study to Assess the Efficacy and Safety of Nemolizumab in Subjects With Systemic Sclerosis
Phase 2Ended 9 Jul 2024
Phase 2Ended 30 Jun 2024
Completed44 participants
NCT01895244
Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis
No phaseEnded 28 Jun 2024
Completed318 participants
NCT05961267
Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism
No phaseEnded 1 Jun 2024
Completed20 participants
NCT04971018
Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Digestive Symptoms in Systemic Sclerosis Systemic Sclerosis
No phaseEnded 30 Apr 2024
No phaseEnded 30 Apr 2024
No phaseEnded 31 Mar 2024
No phaseEnded 29 Mar 2024
No phaseEnded 15 Mar 2024
Not medical advice. fetched 4 Nov 2026