Osteoarthritis: who works on it

One card per institution. Pick a target or a country to narrow the list.

• All targets
• PI3K 0
• NRF2 0
• NLRP3 0
• MAPK 0
• AMPK 1
• GLP-1 3
• IL-1 1
• AKT 0
• mTOR 0
• STAT3 0
• SIRT1 0
• TLR4 0
• JAK 0
• COX-2 0
• ERK 0
• CTNNB1 0
• IL-6 0
• PPAR 0
• STING 0
• TP53 0
• GPX4 0
• HIF-1 0
• JNK 0
• TNF 0
• YAP 0
• PINK1 0
• PTEN 0
• VEGF 0
• IL-17 0
• METTL3 0
• RANKL 0
• EGFR 0
• BCL-2 0
• CXCR4 0
• FTO 0
• HMGB1 0
• MMP-9 0
• SGLT2 1
• CGRP 0
• FGFR 0
• HDAC 0
• KEAP1 0
• MDM2 0
• PARP 0
• APOE 0
• BRD4 0
• CDK4/6 0
• ESR1 0
• FAK 0
• GIP 0
• HER2 0
• HSP90 0
• MEK 0
• NMDA 0
• TREM2 0
• APP 0
• AR 0
• ARID1A 0
• CD47 0
• CFTR 0

24 of 3,100 institutions, ordered by recent publications and open trials. This is not a ranking of quality.

Funded research projects that name this disease in their title, terms or summary and have not ended yet: who is funded, where, how much and until when. Organisations only; the funder's page has the details.

• NIH NIA · F30

  Dissecting Age-related Changes in Stem Cell-based Bone-Gut Crosstalk

  University of California at Davis· Davis, United States· US$43,752 awarded in fiscal year 2026· until Sept 2029

• NIH NINDS · R43

  Development of an Anti-Nerve Growth Factor Active Immunotherapy for Difficult-to-Manage Pain

  Twilight Bioscience, Inc.· Topsfield, United States· US$350,188 awarded in fiscal year 2026· until Aug 2028

• NIH NIAMS · R56

  Understanding the Roles of Synovitis, Knee-Adjacent Obesity and Sarcopenia in Pain Phenotypes and Structural Progression of Knee Osteoarthritis - An Analysis of the Entire Osteoarthritis Initiative

  University of California, San Francisco· San Francisco, United States· US$620,656 awarded in fiscal year 2026· until Aug 2027

• NIH NIAMS · R01

  Fe Metabolism Compromises Articular Chondrocytes during Joint Degeneration

  University of Iowa· Iowa City, United States· US$660,873 awarded in fiscal year 2026· until Aug 2031

• NIH NIDCR · R43

  SN102: a Novel Gene Therapy for Trigeminal Neuralgia Pain

  Sereneuro Therapeutics, Inc.· Baltimore, United States· US$338,115 awarded in fiscal year 2026· until Sept 2027

• European Commission (Horizon Europe) · HORIZON-ERC

  Biofabrication of gene activated grafts targeting synovial joint inflammation and meniscus repair (SMART-MENISCUS)

  The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin· Dublin, Ireland· EU contribution €1,500,000· until Jan 2032

  The disease is named only in the funder's project summary, not in the title.

• European Commission (Horizon Europe) · HORIZON-RIA

  EV-enriched secretome from cord blood as a new disease modifying treatment for osteoarthritis (ExoCordOA)

  Exogenus Therapeutics Sa· Cantanhede, Portugal· EU contribution €13,000,000· until Aug 2031· 3 countries

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Smart Platforms for Osteochondral Regeneration through on-demand Activation (SPORA)

  Instituto Superior Tecnico· Lisboa, Portugal· EU contribution €191,343· until Aug 2028

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Newly engineered lignin nanocarrier for curcumin delivery to tackle inflammation and limited synovial drug residence in osteoarthritis (LigNPsCURCDeLIV)

  University of Leeds· Leeds, United Kingdom· EU contribution €276,188· until Sept 2028

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Gene-activated tri-layer 3D-bioprinted scaffold for enhanced osteochondral defect repair (GATSO-3D)

  Royal College of Surgeons in Ireland· Dublin 2, Ireland· EU contribution €252,729· until Jul 2028

  The disease is named only in the funder's project summary, not in the title.

10 of 488 running projects, newest first. Listed amounts together: US$275.7m + €106.0m.

Sources: NIH RePORTER (U.S. National Institutes of Health, public domain) and CORDIS (European Commission, CC BY 4.0). Changes: filtered by disease, organisations matched to ROR.

Terminated, withdrawn and suspended trials with the reason the sponsor gave in the registry, quoted word for word.

• Terminated

  Rotator Cuff Sparing Total Arthroplasty

  NCT01961986· NYU Langone Health· Updated 13 Nov 2026

  “Terminated because sufficient data has been collected to do analysis and a manuscript has been published.”Registry text, quoted unchanged. Source

• Withdrawn

  Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals

  NCT06701461· Dartmouth-Hitchcock Medical Center· Updated 13 Nov 2026

  “The study was not pursued”Registry text, quoted unchanged. Source

• Terminated

  Preoperative Immunonutrition in Patients Undergoing Spine Surgery

  NCT05372289· I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio· Updated 13 Nov 2026

  “Poor accrual”Registry text, quoted unchanged. Source

• Suspended

  Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)

  NCT06058169· Augusta University· Updated 2 Nov 2026

  “funding issues”Registry text, quoted unchanged. Source

• Withdrawn

  Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE)

  NCT07779629· The First Affiliated Hospital of Shihezi University· Updated 27 Oct 2026

  “This original trial NCT07779629 was withdrawn before any participant enrollment. The protocol was split into two independent new trials: NCT07887126 and NCT07887152. These two new trials have separate IRB approvals and will be conducted and analyzed”Registry text, quoted unchanged. Source

• Terminated

  Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

  NCT04676802· Stanford University· Updated 27 Oct 2026

  “Study drug supply unavailable”Registry text, quoted unchanged. Source

• Terminated

  Evaluation of Structural and Functional Integrity of the Rotator Cuff After Total Shoulder Arthroplasty

  NCT03921944· Milton S. Hershey Medical Center· Updated 20 Oct 2026

  “low enrollment”Registry text, quoted unchanged. Source

• Suspended

  TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios

  NCT04241172· IRCCS San Raffaele Roma· Updated 19 Oct 2026

  “Due to technical issues with the necessary facilities at the participating centers, the PIs have decided to suspend the study until the devices and hydrotherapy pool are fully operational.”Registry text, quoted unchanged. Source

• Terminated

  Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

  NCT04427709· Wake Forest University Health Sciences· Updated 13 Oct 2026

  “This study was initiated for preliminary data to support NIH grant submission. The study was maintained active in anticipation of returning to the protocol. Due to funding and current NIH grant work this study could not be completed.”Registry text, quoted unchanged. Source

• Terminated

  ROSA® Hip System THA PMCF

  NCT05497206· Zimmer Biomet· Updated 13 Oct 2026

  “The data needed for regulatory submissions based on the current pace of the study, will not be available in the foreseeable future.”Registry text, quoted unchanged. Source

Trials whose registry record says individual participant data (IPD) will be shared.

• Intracapsular Injection of Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

  NCT07935083· Beijing Hospital· Source

• Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults

  NCT07330999· Poznan University of Medical Sciences· Source

• Osteoarthritis Care Tools for Primary Care Providers in Family Medicine and Geriatrics Clinics

  NCT07925710· University of North Carolina, Chapel Hill· Source

• Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)

  NCT07473232· Pamukkale University· Source

• The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity

  NCT07921563· Dartmouth-Hitchcock Medical Center· Source

• ESPB vs iPACK+ACB in Total Knee Arthroplasty

  NCT06302218· Poznan University of Medical Sciences· Source

• SIRI Levels Following PENG Block in Hip Arthroplasty

  NCT07449403· Poznan University of Medical Sciences· Source

• Effects of Virtual Reality Environments on Walking in Adults With and Without Knee Osteoarthritis

  NCT07920120· University of Primorska· Source

• ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty

  NCT07677215· Poznan University of Medical Sciences· Source

• A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

  NCT07919678· Pfizer· Source

Find publications on this disease by a MeSH method term, for example a sequencing or imaging method.

• Single-Cell Analysis 43
• Organoids 4
• Mendelian Randomization Analysis 56
• CRISPR-Cas Systems 1
• Gene Expression Profiling 106
• Sequence Analysis, RNA 11
• Whole Genome Sequencing 3
• Exome Sequencing 1
• Proteomics 43
• Metabolomics 26
• Mass Spectrometry 5
• Flow Cytometry 7
• Immunohistochemistry 19
• Positron-Emission Tomography 6
• Magnetic Resonance Imaging 276
• Machine Learning 78
• Deep Learning 45
• Cohort Studies 148
• Genome-Wide Association Study 48

• Distinct Gut Microbiomic and Metabolomic Signatures in Knee and Hip Osteoarthritis.

  J Rheumatol, Oct 2026

• Integrative transcriptomics-metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis.

  Front Immunol, Sept 2026

• Heiguteng Zhuifeng Huoluo capsule alleviates osteoarthritis associated with glycerophospholipid metabolism remodeling and PI3K/AKT/mTOR-related inflammatory signaling.

  Fitoterapia, Sept 2026

• Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review).

  Mol Med Rep, Sept 2026

• Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review).

  Int J Mol Med, Sept 2026

• Fecal microbiota and metabolite profiles in patients with osteoarthritis: a cross-sectional study.

  Front Cell Infect Microbiol, Aug 2026

• Modulating the gut-joint axis: Bifidobacterium longum subsp. infantis B8762 is associated with selective gut microbial and metabolic alterations in knee osteoarthritis.

  World J Microbiol Biotechnol, Aug 2026

• Retsat promotes synovial mesenchymal stem cell senescence and aggravates osteoarthritis by inhibiting the PPARγ/RXR heterodimerization pathway.

  Osteoarthritis Cartilage, Jul 2026

• Osteoarthritis pain inversely correlates with histidine and glutamine following CSF and serum profiling.

  Arthritis Res Ther, Jun 2026

• Multi-omics reveals circadian regulation of bone homeostasis by gut microbiota metabolites: mechanisms and chronotherapeutic implications.

  Front Immunol, May 2026

See which targets of this disease your abstract mentions, and go to the people working on them.