Triple-negative breast cancer: who works on it

One card per institution. Pick a target or a country to narrow the list.

• All targets
• PD-L1 26
• HER2 24
• PD-1 36
• BRCA1 5
• STAT3 1
• STING 0
• EGFR 4
• PI3K 1
• BRCA2 2
• TP53 1
• AKT 0
• PARP 1
• mTOR 0
• TROP2 6
• AR 1
• PTEN 0
• CDK4/6 3
• VEGF 4
• HIF-1 0
• MYC 0
• GPX4 0
• YAP 0
• CTNNB1 0
• JAK 1
• HDAC 0
• MAPK 0
• BCL-2 0
• CXCR4 1
• ERK 0
• NRF2 0
• PPAR 0
• B7-H3 4
• EZH2 0
• FAK 0
• PRMT5 0
• CD47 0
• HSP90 0
• PSMA 4
• IL-6 0
• PIK3CA 2
• CTLA-4 1
• HER3 2
• TNF 0
• COX-2 0
• IGF1R 0
• MEK 0
• FGFR 0
• MDM2 2
• MET 0
• MUC1 3
• NLRP3 0
• PALB2 0
• AMPK 0
• CD40 0
• CSF1R 1
• JNK 0
• METTL3 0
• MMP-9 0
• PKM2 0
• SIRT1 0

6 of 6+ institutions, ordered by recent publications and open trials. This is not a ranking of quality.

Funded research projects that name this disease in their title, terms or summary and have not ended yet: who is funded, where, how much and until when. Organisations only; the funder's page has the details.

• NIH NCI · R15

  Mechanotransduction from the tumor microenvironment to the nuclear envelope protein emerin enables nuclear softening during cancer metastasis

  Rowan University· Glassboro, United States· US$564,078 awarded in fiscal year 2026· until Aug 2029

• NIH NCI · R44

  Enriching and expanding tumor-reactive CD8 T-cells to treat breast cancer

  Agonox, Inc.· Portland, United States· US$977,639 awarded in fiscal year 2026· until Aug 2028

• NIH NCI · K99

  Unlocking Natural Killer cell potential to combat breast cancer metastasis

  University of Colorado Denver· Aurora, United States· US$141,337 awarded in fiscal year 2026· until Aug 2028

• NIH NCI · R43

  Analytical Variables and Clinical Utility of AKT1 Mutation Prediction in Breast Cancer Using Deep Learning on Histopathology Images

  Imagenomix Corp.· Brooklyn, United States· US$157,826 awarded in fiscal year 2026· until Aug 2028

• NIH NCI · R43

  Stable, highly potent and safe lead peptide drug conjugate for the treatment of triple-negative breast cancer.

  Oncotherapy Solutions, Llc· Seattle, United States· US$400,000 awarded in fiscal year 2026· until Sept 2027

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  DuoLipo-TNP: Dual-Responsive Liposome Platform for Selective Delivery of Triphosphate Nucleotide Prodrugs in Triple-Negative Breast Cancer

  Cardiff University· Cardiff, United Kingdom· EU contribution €260,348· until Apr 2029· 2 countries

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Mapping antigenic niches of tumor-infiltrating B cells in triple-negative breast cancer (MAP-BC)

  Karolinska Institutet· Stockholm, Sweden· EU contribution €252,180· until Dec 2028

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-SE

  Biomimetic MXene Nanoplatforms for Targeted Combination Therapy of Triple-Negative Breast Cancer (BioMIX)

  Latvijas Universitate· Riga, Latvia· EU contribution €1,147,740· until Oct 2030· 12 countries

• European Commission (Horizon Europe) · HORIZON-EIC

  Next generation therapeutic vaccine for targeted cancer treatment (VacciNEXT)

  Basinnov Life Sciences Unipessoal Lda· Lisboa, Portugal· EU contribution €2,827,529· until Sept 2029· 3 countries

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Co-culture System with Microfluidics and Onboard Sensors for Breast Cancer study (CoSMOS-BC)

  Universidad del Pais Vasco/ Euskal Herriko Unibertsitatea· Leioa, Spain· EU contribution €209,915· until Aug 2028

  The disease is named only in the funder's project summary, not in the title.

10 of 463 running projects, newest first. Listed amounts together: US$223.8m + €18.5m.

Sources: NIH RePORTER (U.S. National Institutes of Health, public domain) and CORDIS (European Commission, CC BY 4.0). Changes: filtered by disease, organisations matched to ROR.

Terminated, withdrawn and suspended trials with the reason the sponsor gave in the registry, quoted word for word.

• Withdrawn

  Breast Cancer BRCA1 Carriers: a Pilot Study

  NCT05062174· Indiana University· Updated 15 Dec 2022

  “PI decision to cancel research”Registry text, quoted unchanged. Source

Trials whose registry record says individual participant data (IPD) will be shared.

• Safety and Efficacy Study of Enzalutamide in Patients With Advanced, Androgen Receptor-Positive, Triple Negative Breast Cancer

  NCT01889238· Pfizer· Source

Find publications on this disease by a MeSH method term, for example a sequencing or imaging method.

• Single-Cell Analysis 46
• Organoids 9
• Mendelian Randomization Analysis 2
• CRISPR-Cas Systems 10
• Gene Expression Profiling 110
• Sequence Analysis, RNA 8
• Whole Genome Sequencing 4
• Exome Sequencing 5
• Proteomics 32
• Metabolomics 14
• Mass Spectrometry 3
• Flow Cytometry 11
• Immunohistochemistry 49
• Liquid Biopsy 4
• Circulating Tumor DNA 16
• Xenograft Model Antitumor Assays 254
• Positron-Emission Tomography 13
• Magnetic Resonance Imaging 34
• Machine Learning 28
• Deep Learning 15
• Cohort Studies 21
• Genome-Wide Association Study 3

• Uncovering the immune microenvironmental atlas of breast cancer molecular subtypes based on single-cell transcriptomics.

  PLoS One, Nov 2026

• RecurIndex-derived molecular features associated with total pathological complete response in triple-negative breast cancer: An exploratory prospective cohort study with single-cell transcriptomic contextualization.

  Cancer Biol Ther, Oct 2026

• Single-cell multiomics reveals exosome-mediated reprogramming and clonotypic remodeling of T cells in triple-negative breast cancer.

  Signal Transduct Target Ther, Aug 2026

• CD39-associated myeloid-T-cell coordination within an immunoregulatory neighborhood linked to treatment resistance in triple-negative breast cancer.

  Breast Cancer Res, Aug 2026

• Single-cell and spatial transcriptomics reveal that THBS1 induces radiation resistance in TNBC through the interaction between myCAF and TOPBP1⁺ tumor cells.

  J Transl Med, Jul 2026

• Single-cell transcriptomic analysis reveals the immunosuppressive status of NK cell subpopulations in TNBC.

  PLoS One, Jul 2026

• Integrative Single-Cell and Bulk Transcriptomic Analyses with Spatial Validation Identify a Residual Fatty Acid-EMT Subset Driving Chemotherapy Resistance in Triple-Negative Breast Cancer via MIF- and MK-Mediated Ligand-Receptor Signaling.

  Int J Mol Sci, Jul 2026

• scATAnno: Automated Cell Type Annotation for Single-cell ATAC-seq Data.

  Genomics Proteomics Bioinformatics, Jun 2026

• Single-cell profiling reveals a novel CAF subpopulation linking stromal heterogeneity to immune suppression in breast cancer subtypes.

  J Transl Med, Jun 2026

• Imaging-Guided Live Single-Cell Lipid Profiling of Leader and Follower Cells During Collective Migration of Triple-Negative Breast Cancer Cells.

  Adv Sci (Weinh), Jun 2026

See which targets of this disease your abstract mentions, and go to the people working on them.