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Imaging hidden glioblastoma cells in the brain with iron particles

Tests iron oxide particles in MRI scans to spot glioblastoma cells spreading into healthy brain.

Key facts

Who runs it
Stichting Radboud universitair medisch centrum
Where
Nijmegen, NetherlandsSee the site
Registry title
Unravelling the invisiBle infiltRating cOmponeNT Of glioblaStomA Using mRi USpio (BRONTOSAURUS)
Status
Not yet recruiting
Phase
Phase 4
People taking part
15 people, planned
Started
1 Jan 2025
Expected to end
1 Jan 2027
Type of study
Interventional
Record updated
2 December 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with suspected glioblastoma, a type of brain tumour. It studies how far the tumour spreads into healthy brain tissue using a special MRI scan with iron oxide particles.

Age
18 to 75 years
Sex
Men and women can join.
Disease stage
Suspected glioblastoma.
Earlier treatment
People must be able to have brain surgery and/or chemotherapy with radiation.

Main reasons for not taking part

  • Younger than 18 years
  • People who are not fit enough for surgery
  • Tumours that cannot be treated with brain surgery

The registry criteria, word for word

Show all 5 criteriaShow less

Who can take part

  • Diagnosed with suspected glioblastoma
  • Age between 18-75 years
  • Eligible for neurosurgical resection and/or chemoradiation therapy

Who cannot take part

  • Patients unfit for surgery or lesions unsuitable for neurosurgical treatment
  • Younger than 18 years

Where in Netherlands

  • Radboud universitair medisch centrum StichtingNijmegen, NetherlandsNot yet recruiting

About the trial

What the trial wants to find out

To what extent, do GBMs infiltrate healthy brain tissue and can we use ultrasmall superparamagnetic iron oxide particles to visualize co-opting infiltrating tumor cells in an attempt to predict regions of tumor recurrence?

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
Unravelling the invisiBle infiltRating cOmponeNT Of glioblaStomA Using mRi USpio (BRONTOSAURUS)
Plain-language title
Imaging hidden glioblastoma cells in the brain with iron particlesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Record updated
2 December 2024