Glioblastoma trials in Netherlands

In Netherlands 30 Also abroad 424

30 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
Where
Amsterdam, Groningen, Rotterdam
Age
18 years and over
People
450 worldwide
Run by
Bayer
See details and how to joinNCT06914128 · EU 2025-520623-24-00
No phaseNot yet taking people in Netherlands
An Optimization Study Evaluating Safety and Efficacy of the Y-90 Glioblastoma (GBM) Device in Patients With Recurrent GBM
Where
Utrecht
Age
18 years and over
People
30 worldwide
Run by
Boston Scientific Corporation
See details and how to joinNCT07867886
No phaseTaking people
Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery
Where
Rotterdam
Age
18 years and over
People
20
Run by
Erasmus Medical Center
See details and how to joinNCT06617208
Phase 1Not yet taking people in Netherlands
[¹⁸F]MC225 PET Analysis of Blood–Brain Barrier Function in Glioblastomas
Where
Groningen
Age
18 years and over
People
10
Run by
Universitair Medisch Centrum Groningen
See details and how to join2026-526106-32-00 · EU 2026-526106-32-00
No phaseTaking people
Targeted Pediatric High-Grade Glioma Therapy
Where
Utrecht
Age
12 months to 39 years
People
350 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT05839379
Phase 2Taking people
Study of Olutasidenib and Temozolomide in HGG
Where
Utrecht
Age
12 years to 39 years
People
60 worldwide
Run by
Rigel Pharmaceuticals
See details and how to joinNCT06161974
Phase 1Not yet taking people in Netherlands
A Phase I Study using Oncolytic AdenoVirus Immunotherapy with Repeat Administrations in Recurrent GliOblastoma (VIRAGO)
Where
Amsterdam, Rotterdam
Age
18 years and over
People
18
Run by
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
See details and how to join2025-524555-31-00 · EU 2025-524555-31-00
Phase 3Taking people
Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma
Where
Amsterdam, Utrecht
Age
18 years and over
People
50 worldwide
Run by
Telix Pharmaceuticals (Innovations) Pty Limited
See details and how to joinNCT07100730
Early phase 1Taking people
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Where
Utrecht
Age
1 year to 21 years
People
15 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT06333899
Phase 1Not yet taking people in Netherlands
An open-label dose escalation study to estimate maximum tolerated dose (MTD), identify dose-limiting toxicities (DLTs) and study pharmacokinetics following a single dose of intracranially administered temozolomide-based SI-053 as an add-on to the current standard of care (SoC), in adult patients with newly diagnosed glioblastoma (GBM).
Where
Rotterdam
Age
18 years to 64 years
People
27 worldwide
Run by
Double Bond Pharmaceutical AB
See details and how to joinNCT04967690 · EU 2024-515128-35-00
Phase 1Taking people
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
Where
Utrecht
Age
2 years to 21 years
People
208 worldwide
Run by
Sabine Mueller, MD, PhD
See details and how to joinNCT04732065 · EU 2025-521180-13-00
Phase 3Taking people
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study
Where
Leiden, Rotterdam, Tilburg
Age
18 years and over
People
411 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT05904119 · EU 2023-505267-36-00
Phase 1/2Not yet taking people in Netherlands
The ALPINE trial: a phase 1-2 study of intra-arterial [177Lu]Lu-PSMA-I&T for progressive or recurrent intracranial adult type diffuse glioma
Where
Rotterdam
Age
18 years to 64 years
People
28 worldwide
Run by
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
See details and how to join2023-504696-24-00 · EU 2023-504696-24-00
Phase 1Taking people
Study Investigating Tucatinib and Osimertinib Pharmacokinetics in Primary and Metastatic Brain Tumors: the STICK trial
Where
Amsterdam
Age
18 years and over
People
20
Run by
Amsterdam UMC Stichting
See details and how to join2025-522128-28-00 · EU 2025-522128-28-00
Phase 2Taking people
Surgery for Recurrent Glioblastoma
Where
Amsterdam, Nijmegen, The Hague
Age
18 years and over
People
120 worldwide
Run by
Insel Gruppe AG, University Hospital Bern
See details and how to joinNCT02394626
Early phase 1Taking people
PET-imaging of Two Vartumabs in Patients With Solid Tumors
Where
Groningen
Age
18 years and over
People
32
Run by
Var2 Pharmaceuticals
See details and how to joinNCT06645808 · EU 2024-513827-18-00
No phaseTaking people
Glioblastoma Imaging for the Detection of Tumor Progression Using APTw-CEST MRI
Where
Amsterdam, Leiden, Rotterdam, Utrecht
Age
18 years and over
People
120
Run by
Erasmus Medical Center
See details and how to joinNCT07121842
Phase 1Taking people
Phase 0 trial of CBD in recurrent glioblastoma patients
Where
Rotterdam
Age
18 years and over
People
7
Run by
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
See details and how to join2024-513357-74-01 · EU 2024-513357-74-01
No phaseTaking people
Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma
Where
Rotterdam
Age
18 years and over
People
53
Run by
Erasmus Medical Center
See details and how to joinNCT06183983
Phase 4Not yet taking people in Netherlands
Unravelling the invisiBle infiltRating cOmponeNT Of glioblaStomA Using mRi USpio (BRONTOSAURUS)
Where
Nijmegen
Age
18 years and over
People
15
Run by
Stichting Radboud universitair medisch centrum
See details and how to join2024-514013-34-00 · EU 2024-514013-34-00
No phaseTaking people
Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques
Where
Amsterdam
Age
18 years and over
People
30
Run by
Amsterdam UMC, location VUmc
See details and how to joinNCT06623565
Phase 1Taking people
MIRROR; Multispectral and bimodal fluorescent guided surgery (FGS) of high-grade glioma for refining margin assessment: A phase 1 dose finding study using Cetuximab-IRDye800CW- combined with 5-ALA
Where
Groningen
Age
18 years and over
People
21
Run by
Universitair Medisch Centrum Groningen
See details and how to joinNCT05929456 · EU 2024-513392-40-01
No phaseNot yet taking people in Netherlands
FET-PET-Guided Management of Pseudoprogression in Glioblastoma
Where
Amsterdam, Enschede, Groningen, Maastricht, Nijmegen, Rotterdam, The Hague, Utrecht
Age
18 years and over
People
144
Run by
Veerle Ruijters
See details and how to joinNCT06480721
No phaseTaking people
The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
Where
Rotterdam, The Hague
Age
18 years to 90 years
People
464 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06283927
No phaseTaking people
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
Where
Rotterdam, The Hague
Age
18 years to 90 years
People
784 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06118723