Taking people in ItalyPhase 2
Comparing psilocybin and personalized brain stimulation for resistant depression
Tests psilocybin and personalized brain stimulation in adults with treatment-resistant depression.
Key facts
- Who runs it
- Universita' Degli Studi G. D'Annunzio Di Chieti
- Where
- Chieti Scalo, Colleferro (RM), and Foggia, ItalySee the 3 sites
- Trial code
- Registry title
- Psilocybin versus Personalized Neuromodulation for Resistant Depression (PSILO-MODULATION)
- Status
- Recruiting
- Phase
- Phase 2
- People taking part
- 68 people, planned
- Started
- 19 Jan 2026
- Expected to end
- 30 May 2027
- Type of study
- Interventional
- Record updated
- 19 November 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with depression that has not improved after at least two antidepressant medicines. It compares psilocybin with personalized rTMS brain stimulation.
- Age
- 18 to 64 years. The criteria text says 18 to 65 years.
- Sex
- All sexes can join.
- Disease stage
- Treatment-resistant depression: a diagnosis of major depressive disorder (MDD) with no response to at least two antidepressant medicines.
- Earlier treatment
- People must have taken at least two antidepressant medicines at adequate doses for adequate time (4-6 weeks) without response.
Main reasons for not taking part
- Severe organic or neurological illness
- Previous seizures
- Substance use disorders
- Cognitive decline
- Psychotic disorders
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Age between 18 and 65 years
- Diagnosis of TRD: subjects with a MDD diagnosis, non-responders to at least two antidepressant medications at adequate doses administered for adequate time (i.e., 4-6 weeks)
Who cannot take part
- Previous episodes of seizures
- Substance use disorders
- Psychotic disorders
- Presence of severe organic/neurological comorbidities
- Cognitive decline
- Pregnancy/postpartum state
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Italy
- Universita' Degli Studi G. D'Annunzio Di ChietiChieti Scalo, ItalyTaking people
- ASL Roma 5Colleferro (RM), ItalyTaking people
- Azienda Ospedaliero Universitaria - Policlinico Riuniti FoggiaFoggia, ItalyTaking people
About the trial
What the trial wants to find out
Compare the effectiveness of psilocybin and personalized rTMS in Treatment Resistant Depression (TRD)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record
Print a page for my doctorData and sources
- Registry record
- Listed on the EU's official list of trials (CTIS).
- Official title
- Advancing PRecise Interventions for resistant DEpression: rebalancing brain networks and investigating the trajectories of antidepressant effect with psilocybin and personalized neuromodulation (PRIDE)
- Plain-language title
- Comparing psilocybin and personalized brain stimulation for resistant depressionGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 9 November 2026.
- Fit questions
- Built from 2024-519844-34-03, who can take part
- Record updated
- 19 November 2025