Depression trials in Italy

In Italy 21 Also abroad 666

21 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A research study to compare the antidepressant ability and safety of Samyr® tablets versus placebo tablets as an adjunct to additional antidepressant treatment in patients with major depressive disorder (MDD)
Where
Albese con Cassano - Como, Alexandria, Bergamo, Białystok, Catania, Milan, Monza, Pavia, Rome, Salerno
Age
18 years and over
People
868 worldwide
Run by
Mylan Inc.
See details and how to join2024-513019-29-00 · EU 2024-513019-29-00
Phase 2Not yet taking people in Italy
Targeting inflammation in depression using Minocycline: a patient stratification approach using peripheral inflammatory biomarkers and MRI
Where
Brescia
Age
18 years and over
People
100
Run by
Provincia Lombardo Veneta Dell’Ordine Ospedaliero Di San Giovanni Di Dio Fatebenefratelli
See details and how to joinNCT06207760 · EU 2024-520076-10-01
Phase 3Taking people
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Where
Brescia, Catania, Chieti, Genoa, Monza, Padova, Pisa, Rome, Salerno, Siena
Age
18 years to 74 years
People
752 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06559306 · EU 2023-509070-36-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Where
Bolzano, Cagliari, Catania, Florence, Foggia, Genoa, Naples, Sassari
Age
12 years to 17 years
People
258 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07227454 · EU 2024-518615-19-00
Phase 3Taking people
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Milan, Rome, Turin
Age
18 years and over
People
850 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06966401 · EU 2024-519423-24-00
No phaseTaking people
Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression
Where
Brescia, Ospitaletto
Age
55 years to 80 years
People
120
Run by
IRCCS Centro San Giovanni di Dio Fatebenefratelli
See details and how to joinNCT06990035
Phase 3Taking people
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Milan, Rome, Turin
Age
18 years and over
People
550 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT07196501 · EU 2025-520541-72-00
Phase 2Taking people
Trazodone’s Effects on Moderation of Psilocybin Outcomes (TEMPO)
Where
Chieti Scalo
Age
18 years to 64 years
People
30
Run by
Universita' Degli Studi G. D'Annunzio Di Chieti
See details and how to join2025-523346-27-00 · EU 2025-523346-27-00
Phase 3Taking people
A study to evaluate Samyr effectiveness and safety profile. The study is done by comparing that Samyr injection is better than placebo injection in subjects with depression which are treated regularly with antidepressant tablet treatment.
Where
Giulianova, Padova, Pisa
Age
18 years to 64 years
People
468
Run by
Mylan Inc.
See details and how to join2024-513022-29-00 · EU 2024-513022-29-00
No phaseNot yet taking people in Italy
Non-Coding RNAs Gene Expression in Psychiatric Disorders
Where
Catania, Enna, Messina, Palermo
Age
18 years to 55 years
People
384
Run by
Carmen Concerto
See details and how to joinNCT07649993
Phase 3Taking people
Ketamine Augmentation of ECT in Treatment-Resistant Depression
Where
Milan
Age
18 years to 70 years
People
30
Run by
Università Vita-Salute San Raffaele
See details and how to joinNCT07088380
No phaseTaking people
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Where
Chieti, Genova, Milan, Pavia
Age
18 years to 74 years
People
100
Run by
Riccardo Guglielmo
See details and how to joinNCT07146503
Phase 3Taking people
The additive effect of ketamine in combination with electroconvulsive stimulation (ECS) in major depressive disorder (MDD): a translational study
Where
Milan
Age
18 years and over
People
30
Run by
Universita' Vita-salute S. Raffaele
See details and how to join2024-512559-20-01 · EU 2024-512559-20-01
No phaseTaking people
Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice
Where
Brescia
Age
50 years to 80 years
People
120
Run by
IRCCS Centro San Giovanni di Dio Fatebenefratelli
See details and how to joinNCT07009223
Phase 4Taking people
A randomized, double-blind, placebo-controlled, multicenter clinical trial to assess safety and effectiveness of Liposom in enhance and speed up response to antidepressant therapy with citalopram in elderly patients suffering from Major Depressive Disorder (MDD)
Where
Avezzano, Milan, Rome
Age
65 years and over
People
150
Run by
Fidia Farmaceutici S.p.A.
See details and how to joinNCT04975724 · EU 2024-512293-10-00
Phase 2Taking people
Psilocybin versus Personalized Neuromodulation for Resistant Depression (PSILO-MODULATION)
Where
Chieti Scalo, Colleferro (RM), Foggia
Age
18 years to 64 years
People
68
Run by
Universita' Degli Studi G. D'Annunzio Di Chieti
See details and how to join2024-519844-34-03 · EU 2024-519844-34-03
Phase 3Taking people
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Where
Brescia, Cagliari, Naples, Turin
Age
18 years and over
People
418 worldwide
Run by
Dr. Inge Winter
See details and how to joinNCT05973786 · EU 2023-506605-19-00
Phase 3Taking people
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Where
Brescia, Cagliari, Naples, Turin
Age
18 years to 65 years
People
418 worldwide
Run by
Dr. Inge Winter
See details and how to joinNCT05973851 · EU 2023-506617-21-00
Phase 4Taking people
PILOT STUDY ON THE EFFECTIVENESS OF CHOLINE ALFOSCERATE IN THE UNDER THRESHOLD DEPRESSION OF THE ELDERLY
Where
Lodi
Age
18 years and over
People
20
Run by
Azienda Socio Sanitaria Territoriale Di Lodi
See details and how to join2025-520899-25-00 · EU 2025-520899-25-00
Phase 2Taking people
Evaluation of p-glycoprotein alterations in treatment-resistant depression: a [18F]MC225 PET study
Where
Rome
Age
18 years and over
People
44
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to join2023-508303-20-01 · EU 2023-508303-20-01
No phaseTaking people
Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression
Where
Chieti
Age
18 years to 65 years
People
80
Run by
ITAB - Institute for Advanced Biomedical Technologies
See details and how to joinNCT05798143