Collects samples and brain scans from people with mood or psychotic disorders
Studies DNA, brain scans and clinical assessments in people with depression, bipolar or psychotic disorders.
Plain-language title generated from the registry record
Registry title: Psychiatric Genotype/Phenotype Project Repository
Key facts
- Where
- Nashville, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 65 years old?
Source: NCT00762866, who can take part
Where in United States
- Vanderbilt University Medical CenterNashville, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vanderbilt University
- Trial code
- NCT00762866
- Record updated
- 27 January 2026
- Original description
The purpose of this project is to obtain DNA, brain imaging data, other biological samples (e.g., urine, serum), and a comprehensive clinical assessment on patients with schizophrenia and other psychotic disorders, bipolar disorder, major depression, and normal volunteer controls. Understanding the physical and genetic factors related to these disorders will help us make progress in fitting treatments to an individual's needs. Participants will take part in a detailed clinical assessment, two blood draws, and an MRI scan over two visits. Participants will also be asked to provide urine and saliva samples.Read full original descriptionShow less
Psychiatric Genotype/Phenotype Project
The purpose of this project is to obtain DNA, brain imaging data, other biological samples (e.g., urine, serum), and a comprehensive clinical assessment on patients with schizophrenia and other psychotic disorders, bipolar disorder, major depression, and normal volunteer controls. Understanding the physical and genetic factors related to these disorders will help us make progress in fitting treatments to an individual's needs. Participants will take part in a detailed clinical assessment, two blood draws, and an MRI scan over two visits. Participants will also be asked to provide urine and saliva samples.
Inclusion: Between the ages of 16 and 65; Able and willing to provide informed consent; Able to read and speak English sufficiently to provide consent and answer questions; Diagnosis of one of the following:; Unipolar Major Depressive Disorder of any subtype; Bipolar I, Bipolar II Disorder, or Bipolar Disorder NOS; Axis I Psychotic Disorder, which can include the diagnoses of Schizophrenia, Schizoaffective Disorder, Major Depression or Mania with Psychotic Features, Schizophreniform Disorder, Brief Psychotic Episode, or Psychotic Disorder NOS; Normal volunteer controls, individuals with no personal history of any Axis I disorder.
Exclusion: Dementia or delirium; Any medical condition that would interfere with participation in the study. This would include, but not be limited to:; uncontrolled diabetes, hypothyroidism, Cushing's disease, or other significant endocrine condition (treated endocrine condition is allowed); demyelinating disease; HIV infection; active hepatitis; CNS infection; clinically significant and unstable cardiovascular disease; any cancer involving the CNS (including metastatic disease); Exclusion criteria for normal control subjects include any history of mental illness or psychotropic drug abuse; Participants will be excluded from the imaging portion of the study if they have any condition deemed to interfere with PET or MRI scanning, such as but not restricted to extreme obesity, metal fragments in eyes, metal implants in the head, or cochlear implant. These participants may still take part in the portion of the study involving the clinical assessment and providing biological samples; Reported pregnancy or breastfeeding.