Bipolar disorder trials in United States

In United States 94 Also abroad 235

94 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Natural History of Depression, Bipolar Disorder and Suicide Risk
Where
Bethesda
Age
18 years to 120 years
People
500
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT06462196
No phaseTaking people
Safety and Feasibility of DBS for Bipolar Depression
Where
New York
Age
22 years to 70 years
People
5
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07745374
Phase 2Taking people
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Where
Atlanta, Bellevue, Clinton, Fairfax, Gaithersburg, Hialeah, Maitland, McKinney, Miami Lakes, Naples, New Haven, Orange, Orlando, Philadelphia, Richardson, Springfield, Waterloo, Watertown, Weston
Age
18 years to 75 years
People
400 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07286175
Phase 3Taking people
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Where
Anaheim, Atlanta, Avon Lake, Bellevue, Bloomfield Hills, Cincinnati, Colorado Springs, Coppell, Everett, Fort Myers, Fort Worth, Gainesville, Garden Grove, Garfield Heights, Hialeah, Homestead, Houston, Indianapolis, Jacksonville, Las Vegas, Lawrenceville, Lincoln, Little Rock, Miami, Miami Gardens, Miami Lakes, Naperville, Nashville, New York, Norman, Oceanside, Oklahoma City, Orlando, Phoenix, Plano, Pompano Beach, Redlands, Richmond, Sacramento, Saint Charles, San Diego, Savannah, Staten Island, St. Petersburg, West Covina, West Palm Beach
Age
5 years to 17 years
People
300 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06229210 · EU 2023-507068-38-00
Phase 3Taking people
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Where
Anaheim, Atlanta, Austin, Avon Lake, Baltimore, Beaumont, Bellevue, Bloomfield Hills, Chicago, Cincinnati, Colorado Springs, Dothan, Elgin, Everett, Flower Mound, Fort Myers, Garfield Heights, Hialeah, Homestead, Houston, Indianapolis, Lawrenceville, Lincoln, Little Rock, Miami, Miami Gardens, Miami Lakes, New York, Oklahoma City, Orlando, Redlands, Richmond, Sacramento, Saint Charles, San Diego, Savannah, St Louis, West Covina, Westlake, West Palm Beach
Age
10 years to 17 years
People
384 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06372964
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Where
Austin, Bellflower, Bentonville, Boynton Beach, Chicago, Chino, Culver City, DeSoto, Hallandale, Houston, Indianapolis, La Habra, Little Rock, Mansfield, Miami, Montclair, Orange, Richardson, Riverside, Savannah, Staten Island, St Louis
Age
18 years to 65 years
People
424 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07140913
Phase 2Not yet taking people in United States
N-Acetylcysteine for Bipolar and Alcohol Use Disorders
Where
Charleston
Age
18 years to 60 years
People
70
Run by
Medical University of South Carolina
See details and how to joinNCT07913542
Phase 3Taking people
A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)
Where
Anaheim, Atlanta, Austin, Bellflower, Bentonville, Boynton Beach, Carrollton, Cerritos, Charlotte, Chicago, Chino, Cincinnati, Culver City, Decatur, DeSoto, Flowood, Gaithersburg, Garden Grove, Glendale, Hallandale, Hialeah Gardens, Hollywood, Houston, Indianapolis, Irving, La Habra, Lincoln, Little Rock, Mansfield, Marlton, Miami, Miami Lakes, Miami Springs, Montclair, New Haven, North Canton, North Las Vegas, Northridge, Orange, Richardson, Riverside, Rogers, Santa Ana, Savannah, Scottsdale, Staten Island, St Louis, St. Petersburg, Torrance, Tucson, West Chester, Wichita Falls
Age
18 years to 65 years
People
450 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06929273 · EU 2024-520259-26-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
Where
Anaheim, Atlanta, Austin, Bellflower, Bentonville, Cerritos, Chicago, Hollywood, Homestead, Irving, Little Rock, Long Beach, Los Angeles, Miami, Miami Lakes, Montclair, New Haven, North Canton, Richardson, Savannah, Staten Island, West Palm Beach
Age
18 years to 65 years
People
274 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06951698
No phaseEnrolling by invitation
Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization
Where
McKeesport, Pittsburgh
Age
18 years to 65 years
People
1,000
Run by
Stanford University
See details and how to joinNCT07130500
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)
Where
Atlanta, Boynton Beach, Charlotte, Chicago, Cincinnati, Culver City, Decatur, DeSoto, Flowood, Gaithersburg, Hialeah Gardens, Hollywood, Houston, Little Rock, Marlton, Miami, Miami Lakes, Miami Springs, North Canton, North Las Vegas, Richardson, Riverside, Rogers, St Louis, Tampa, Torrance
Age
18 years to 65 years
People
274 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06951711
Phase 2Taking people
ALTO-100 in Bipolar Disorder With Depression (BD-D)
Where
Albuquerque, Amherst, Ann Arbor, Atlanta, Austin, Baltimore, Beaumont, Bel Air, Bellevue, Birmingham, Carmel, Cary, Chandler, Chicago, Chino, Cincinnati, Colorado Springs, Dallas, Draper, Fairfax, Fayetteville, Flowood, Gaithersburg, Grand Rapids, Houston, Imperial, Jacksonville, Las Vegas, Lauderhill, Lincoln, Little Rock, Los Angeles, Mather, New York, North Canton, Oceanside, Peachtree Corners, Phoenix, Pinellas Park, Plano, Riverside, Rose Hill, Sacramento, San Jose, Tampa, Toms River, Towson, West Lafayette, Westlake, Worcester, Yuma
Age
18 years to 70 years
People
200 worldwide
Run by
Alto Neuroscience
See details and how to joinNCT06656416
No phaseTaking people
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
Where
Cleveland
Age
18 years and over
People
100
Run by
University Hospitals Cleveland Medical Center
See details and how to joinNCT03829787
No phaseTaking people
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Where
Bethesda
Age
8 years to 70 years
People
1,260
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT05669703
No phaseTaking people
Time Restricted Eating (TRE) in Bipolar Disorder
Where
Boston
Age
18 years to 65 years
People
40
Run by
Massachusetts General Hospital
See details and how to joinNCT07211217
No phaseNot yet taking people in United States
Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area
Where
Montgomery
Age
18 years and over
People
100
Run by
University of Alabama at Birmingham
See details and how to joinNCT07570875
No phaseTaking people
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
Where
Bethesda
Age
3 years to 99 years
People
16,000
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT00024635
No phaseTaking people
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Where
Minneapolis
Age
18 years and over
People
20
Run by
VA Office of Research and Development
See details and how to joinNCT05491538
Phase 4Taking people
Safety and Tolerability of Open-Labeled Iloperidone in Adolescents
Where
Atlanta, Cincinnati, Decatur, Denver, Dothan, Everett, Garfield Heights, Kinston, Little Rock, Westlake
Age
12 years to 17 years
People
100
Run by
Vanda Pharmaceuticals
See details and how to joinNCT05648591
No phaseEnrolling by invitation
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
Where
Providence
Age
18 years and over
People
180
Run by
Butler Hospital
See details and how to joinNCT05703412
Phase 2Taking people
An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania
Where
Atlanta, Austin, Cerritos, Gaithersburg, Garden Grove, Hollywood, Houston, Little Rock, Marlton, San Diego, Staten Island
Age
18 years to 65 years
People
150
Run by
Neurocrine Biosciences
See details and how to joinNCT07288320
No phaseNot yet taking people in United States
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders
Where
Minneapolis
Age
21 years and over
People
138
Run by
VA Office of Research and Development
See details and how to joinNCT07845409
No phaseTaking people
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
Where
Bethesda
Age
7 years to 85 years
People
2,350
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT00025935
Phase 4Taking people
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
Where
New York
Age
18 years to 70 years
People
62
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07680153
No phaseTaking people
State Representation in Early Psychosis 2
Where
Minneapolis
Age
15 years to 45 years
People
500
Run by
University of Minnesota
See details and how to joinNCT07834203